One is not enough: understanding and modeling polysubstance use

EA Crummy, TJ O'Neal, BM Baskin… - Frontiers in …, 2020 - frontiersin.org
Substance use disorder (SUD) is a chronic, relapsing disease with a highly multifaceted
pathology that includes (but is not limited to) sensitivity to drug-associated cues, negative …

A microbiome-dependent gut–brain pathway regulates motivation for exercise

L Dohnalová, P Lundgren, JRE Carty, N Goldstein… - Nature, 2022 - nature.com
Exercise exerts a wide range of beneficial effects for healthy physiology 1. However, the
mechanisms regulating an individual's motivation to engage in physical activity remain …

How changes in dopamine D2 receptor levels alter striatal circuit function and motivation

EH Simpson, EF Gallo, PD Balsam, JA Javitch… - Molecular …, 2022 - nature.com
It was first posited, more than five decades ago, that the etiology of schizophrenia involves
overstimulation of dopamine receptors. Since then, advanced clinical research methods …

Obesity-induced cellular senescence drives anxiety and impairs neurogenesis

M Ogrodnik, YI Zhu, LGP Langhi, T Tchkonia, P Krüger… - Cell metabolism, 2019 - cell.com
Cellular senescence entails a stable cell-cycle arrest and a pro-inflammatory secretory
phenotype, which contributes to aging and age-related diseases. Obesity is associated with …

Long-term high-fat diet consumption by mice throughout adulthood induces neurobehavioral alterations and hippocampal neuronal remodeling accompanied by …

H Zhuang, X Yao, H Li, Q Li, C Yang, C Wang… - Brain, behavior, and …, 2022 - Elsevier
High-fat diet (HFD) consumption is generally associated with an increased risk of cognitive
and emotional dysfunctions that constitute a sizeable worldwide health burden with …

Low-dose stevia (rebaudioside A) consumption perturbs gut microbiota and the mesolimbic dopamine reward system

JE Nettleton, T Klancic, A Schick, AC Choo, J Shearer… - Nutrients, 2019 - mdpi.com
Stevia is a natural low-calorie sweetener that is growing in popularity in food and beverage
products. Despite its widespread use, little is understood of its impact on the gut microbiota …

Why do mice overeat high‐fat diets? How high‐fat diet alters the regulation of daily caloric intake in mice

JA Licholai, KP Nguyen, WC Fobbs, CJ Schuster… - …, 2018 - Wiley Online Library
Objective Ad libitum high‐fat diets (HFDs) spontaneously increase caloric intake in rodents,
which correlates positively with weight gain. However, it remains unclear why rodents …

[HTML][HTML] Xiaoyao San ameliorates high-fat diet-induced anxiety and depression via regulating gut microbiota in mice

Y Yang, Z Zhong, B Wang, Y Wang - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Obesity, a growing health problem in the world, is related to a series of mental disorders,
including anxiety and depression. XiaoYao San (XYS), a prescription of traditional Chinese …

Nucleus accumbens d1 receptor–expressing spiny projection neurons control food motivation and obesity

BA Matikainen-Ankney, AA Legaria, Y Pan… - Biological …, 2023 - Elsevier
Background Obesity is a chronic relapsing disorder that is caused by an excess of caloric
intake relative to energy expenditure. There is growing recognition that food motivation is …

Objectively measured sedentary time and physical activity and associations with body weight gain: does body weight determine a decline in moderate and vigorous …

U Ekelund, E Kolle, J Steene-Johannessen… - International journal of …, 2017 - nature.com
Objectives: High levels of physical activity (PA) may prevent the development of obesity.
However, the magnitude and direction of the association between PA of various intensities …