Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally
regulate each other, are among the well-known cancer hallmarks. Recent evidence …

The changes associated with malignancy are not only in cancer cells but also in
environment in which cancer cells live. Metabolic reprogramming supports tumor cell high …

A wide spectrum of metabolites (mainly, the three major nutrients and their derivatives) can
be sensed by specific sensors, then trigger a series of signal transduction pathways and …

Summary Interleukin-1β (IL-1β) is a key protein in inflammation and contributes to tumor
progression. However, the role of IL-1β in cancer is ambiguous or even contradictory. Here …

Abstract α-Enolase 1 (ENO1) is a critical glycolytic enzyme whose aberrant expression
drives the pathogenesis of various cancers. ENO1 has been indicated as having additional …

Digested dietary fats are taken up by enterocytes where they are assembled into pre-
chylomicrons in the endoplasmic reticulum followed by transport to the Golgi for maturation …

Itaconate is a well-known immunomodulatory metabolite; however, its role in hepatocellular
carcinoma (HCC) remains unclear. Here, we find that macrophage-derived itaconate …

Background Therapies are urgently required to ameliorate pathological cardiac hypertrophy
and enhance cardiac function in heart failure. Our preliminary experiments have …

Mitochondrial succinate dehydrogenase (SDH), also known as electron transport chain
(ETC) Complex II, is the only enzyme complex engaged in both oxidative phosphorylation …

Mitochondrial complex II is traditionally studied for its participation in two key respiratory
processes: the electron transport chain and the Krebs cycle. There is now a rich body of …