The complex functions of the liver in biosynthesis, metabolism, clearance, and host defense
are tightly dependent on an adequate microcirculation. To guarantee hepatic homeostasis …

A type III secretion system (TTSS) is encoded on a virulence plasmid that is common to three
pathogenic Yersinia species: Y. enterocolitica, Y. pseudotuberculosis, and Y. pestis …

The macrophage NLRC4 inflammasome drives potent innate immune responses against
Salmonella by eliciting caspase-1-dependent proinflammatory cytokine production (eg …

Bacteria-driven drug-delivery systems have attracted great attention for their enhanced
therapeutic specificity and efficacy in cancer treatment. YB1, a particularly attractive …

Inflammasomes are cytosolic multiprotein complexes assembled by intracellular nucleotide-
binding oligomerization domain (NOD)-like receptors (NLRs) and they initiate innate …

Neutrophils are prominent participants in the joint inflammation of human rheumatoid
arthritis (RA) patients, but the extent of their role in the inductive phase of joint inflammation …

Inflammasomes can prevent systemic dissemination of enteropathogenic bacteria. As
adapted pathogens including Salmonella Typhimurium (S. Tm) have evolved evasion …

The myeloid differentiation primary response gene 88 (Myd88) is critical for protection
against pathogens. However, we demonstrate here that MyD88 expression in B cells inhibits …

Initiation of the adaptive immune response to Mycobacterium tuberculosis occurs in the lung-
draining mediastinal lymph node and requires transport of M. tuberculosis by migratory …

Salmonella typhimurium is considered a facultative intracellular pathogen, but its
intracellular location in vivo has not been demonstrated conclusively. Here we describe the …