Neurofibromatosis type 1 (NF1) is one of the most common brain tumor predisposition
syndromes, in which affected children are prone to the development of low-grade gliomas …

Despite the fact that they are not typically life-threatening, low-grade gliomas (LGGs) remain
a significant clinical challenge in pediatric neuro-oncology due to comorbidities associated …

Purpose BRAF V600E is a potentially highly targetable mutation detected in a subset of
pediatric low-grade gliomas (PLGGs). Its biologic and clinical effect within this diverse group …

Background. Activation of the mitogen-activated protein kinase pathway is important for
growth of pediatric low-grade gliomas (LGGs). The aim of this study was to determine the …

Pediatric low-grade gliomas encompass a heterogeneous set of tumors of different
histologies. Cerebellar pilocytic astrocytomas occur most frequently followed by …

Purpose To evaluate the efficacy of single-agent vinblastine in pediatric patients with
recurrent or refractory low-grade glioma. Patients and Methods Patients were eligible if they …

Neurofibromatosis type 1 (NF1) is an autosomal dominant tumor predisposition syndrome
that affects children and adults. Individuals with NF1 are at high risk for central nervous …

Background A phase II study of bevacizumab (BVZ) plus irinotecan (CPT-11) was conducted
in children with recurrent low-grade glioma to measure sustained response and/or stable …

Although standard chemotherapy remains the mainstay of ONG treatment, newer
molecularly targeted therapies such as mitogen-activated protein kinase kinase inhibitors …

✓ Optic pathway gliomas represent approximately 3–5% of childhood intracranial tumors.
They usually occur in children during the first decade of life and are seen in 11–30% of …