Increasing evidence suggests that abnormal cerebral glucose metabolism is largely present
in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a …

The blood–brain barrier (BBB) plays a vital role in maintaining the specialized
microenvironment of the neural tissue. It separates the peripheral circulatory system from the …

Therapies targeting late events in Alzheimer's disease (AD), including aggregation of
amyloid beta (Aβ) and hyperphosphorylated tau, have largely failed, probably because they …

Background: Preservation of brain health has emerged as a leading public health priority for
the aging world population. Advances in neurovascular biology have revealed an intricate …

Introduction: Alzheimer's disease (AD) is characterized by cerebral glucose
hypometabolism. Hypometabolism may be partly due to reduced glucose transport at the …

The literature on large‐scale resting‐state functional brain networks across the adult
lifespan was systematically reviewed. Studies published between 1986 and July 2021 were …

Neuropathological diagnostic criteria of neurodegenerative disorders are based on the
presence of specific inclusions in a specific area of brain tissue that correlate with clinical …

Reductions of baseline cerebral blood flow (CBF) of∼ 10–20% are a common symptom of
Alzheimer's disease (AD) that appear early in disease progression and correlate with the …

The 18 kDa translocator protein (TSPO) is increasingly used to study brain and spinal cord
inflammation in degenerative diseases of the CNS such as multiple sclerosis. The enhanced …

White matter (WM) disease is associated with disruption of the gliovascular unit, which
involves breach of the blood–brain barrier (BBB). We quantified pericytes as components of …