A subset of eukaryotic transcription factors possesses the remarkable ability to reprogram
one type of cell into another. The transcription factors that reprogram cell fate are invariably …

The ability to reprogram somatic cells into induced pluripotent stem cells (iPSCs) using
defined factors provides new tools for biomedical research. However, some iPSC clones …

Summary Oct4, Sox2, Klf4, and cMyc (OSKM) reprogram somatic cells to pluripotency. To
gain a mechanistic understanding of their function, we mapped OSKM-binding, stage …

The DNA methylation levels of certain CpG sites are thought to reflect the pace of human
aging. Here, we developed a robust predictor of mouse biological age based on 90 CpG …

Human induced pluripotent stem cells (hiPSCs,,) are useful in disease modeling and drug
discovery, and they promise to provide a new generation of cell-based therapeutics. To date …

Accumulating evidence indicates that circular RNAs (circRNAs) are abundant in the human
transcriptome. However, their involvement in biological processes, including pluripotency …

Somatic cells can be reprogrammed into pluripotent stem cells (PSCs) by using pure
chemicals, providing a different paradigm to study somatic reprogramming. However, the …

Induced pluripotent stem cells (iPSCs) hold great promise for regenerative medicine;
however, their potential clinical application is hampered by the low efficiency of somatic cell …

Oct4 is widely considered the most important among the four Yamanaka reprogramming
factors. Here, we show that the combination of Sox2, Klf4, and cMyc (SKM) suffices for …

The field of regenerative medicine is looking for a pluripotent/multipotent stem cell able to
differentiate across germ layers and be safely employed in therapy. Unfortunately, with the …