Myelination of axons in the nervous system of vertebrates enables fast, saltatory impulse
propagation, one of the best-understood concepts in neurophysiology. However, it took a …

Myelinated nerve fibers are essential for the rapid propagation of action potentials by
saltatory conduction. They form as the result of reciprocal interactions between axons and …

Axons are electrically excitable, cable-like neuronal processes that relay information
between neurons within the nervous system and between neurons and peripheral target …

Oligodendrocytes, the myelin-forming cells of the central nervous system (CNS), and
astrocytes constitute macroglia. This review deals with the recent progress related to the …

Myelination of axons provides the structural basis for rapid saltatory impulse propagation
along vertebrate fiber tracts, a well-established neurophysiological concept. However …

Two proteolipid proteins, PLP and DM20, are the major membrane components of central
nervous system (CNS) myelin. Mutations of the X-linked PLP/DM20 gene cause …

By imposing saltatory conduction on the nervous impulse, the principal role of the myelin
sheath is to allow the faster propagation of action potentials along the axons which it …

The adhesion molecule L1 is a member of the immunoglobulin super-family1. L1 is involved
in various recognition processes in the CMS and PNS2–3, and binding to L1 can activate …

Inherited neuropathies are caused by dominant or recessive mutations in genes that are
expressed by neurons and/or Schwann cells. In demyelinating neuropathies, the deleterious …

Peripheral myelin protein PMP22 has been suggested to have a role in peripheral nerve
myelination and cell proliferation. Defects at the PMP22 locus are associated with peripheral …