Gout is a common inflammatory arthritis caused by the deposition of sodium urate crystals in
the joints. Hyperuricemia is the fundamental factor of gout. The onset of hyperuricemia is …

Background Allopurinol is the primary therapy for the management of chronic gout.
Utilization of allopurinol has increased in tandem with the growing prevalence of gout …

Objective To evaluate the use of prospective screening for the HLA-B* 58: 01 allele to
identify Taiwanese individuals at risk of severe cutaneous adverse reactions (SCARs) …

Summary Background HLA‐B* 58: 01 is associated with allopurinol‐induced severe
cutaneous adverse drug reactions (sCADR) particularly in Han Chinese, but the risk in …

Background Gout is the most common cause of inflammatory arthritis worldwide, particularly
in Pacific regions. We aimed to establish the prevalence of gout and hyperuricaemia in …

Allopurinol hypersensitivity syndrome (AHS) is a severe and sometimes life-threatening
adverse drug reaction. Although AHS is rare, the number of patients with gout requiring …

Allopurinol, a common drug for treating hyperuricemia, is associated with cutaneous
adverse drug reactions ranging from mild maculopapular exanthema to life-threatening …

Genetic polymorphism in the genes encoding the human leukocyte antigen (HLA) molecules
enables presentation of a wide range peptide ligands thus maximising immune surveillance …

Severe cutaneous adverse reactions (SCAR), such as Stevens-Johnson syndrome (SJS),
toxic epidermal necrolysis (TEN), and drug rash with eosinophilia and systemic symptoms …

Stevens‐Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are life‐threatening
disease. However, there are only few epidemiologic studies of SJS/TEN from China. To …