Building machines with DNA molecules

H Ramezani, H Dietz - Nature Reviews Genetics, 2020 - nature.com
In nature, DNA molecules carry the hereditary information. But DNA has physical and
chemical properties that make it attractive for uses beyond heredity. In this Review, we …

High-speed atomic force microscopy for filming protein molecules in dynamic action

T Ando, S Fukuda, KX Ngo… - Annual Review of …, 2023 - annualreviews.org
Structural biology is currently undergoing a transformation into dynamic structural biology,
which reveals the dynamic structure of proteins during their functional activity to better …

Rational design of DNA nanostructures for single molecule biosensing

M Raveendran, AJ Lee, R Sharma, C Wälti… - Nature …, 2020 - nature.com
The ability to detect low concentrations of biomarkers in patient samples is one of the
cornerstones of modern healthcare. In general, biosensing approaches are based on …

Single-molecule analysis and engineering of DNA motors

S Mohapatra, CT Lin, XA Feng, A Basu, T Ha - Chemical reviews, 2019 - ACS Publications
Molecular motors are diverse enzymes that transduce chemical energy into mechanical
work and, in doing so, perform critical cellular functions such as DNA replication and …

Nanopore fingerprinting of supramolecular DNA nanostructures

S Confederat, I Sandei, G Mohanan, C Wälti, P Actis - Biophysical Journal, 2022 - cell.com
DNA nanotechnology has paved the way for new generations of programmable
nanomaterials. Utilizing the DNA origami technique, various DNA constructs can be …

Concepts and Application of DNA Origami and DNA Self‐Assembly: A Systematic Review

W Liu, H Duan, D Zhang, X Zhang… - Applied Bionics and …, 2021 - Wiley Online Library
With the arrival of the post‐Moore Era, the development of traditional silicon‐based
computers has reached the limit, and it is urgent to develop new computing technology to …

Automated purification of DNA origami with SPRI beads

C Chau, G Mohanan, I Macaulay, P Actis, C Wälti - Small, 2024 - Wiley Online Library
DNA origami synthesis is a well‐established technique with wide‐ranging applications. In
most cases, the synthesized origami must be purified to remove excess materials such as …

Analysis of 2D DNA origami with nanopipettes

M Raveendran, AJ Lee, C Wälti, P Actis - ChemElectroChem, 2018 - Wiley Online Library
Nanopipettes are a useful tool for the detection and analysis of biological molecules at the
single‐molecule level. Here, we employ nanopipettes fabricated from glass capillaries to …

Direct observation and analysis of TET-mediated oxidation processes in a DNA origami nanochip

X Xing, S Sato, NK Wong, K Hidaka… - Nucleic Acids …, 2020 - academic.oup.com
DNA methylation and demethylation play a key role in the epigenetic regulation of gene
expression; however, a series of oxidation reactions of 5-methyl cytosine (5mC) mediated by …

Direct observation and analysis of the dynamics of the photoresponsive transcription factor GAL4

G Raghavan, K Hidaka, H Sugiyama… - Angewandte Chemie …, 2019 - Wiley Online Library
Herein, the direct visualization of the dynamic interaction between a photoresponsive
transcription factor fusion, GAL4–VVD, and DNA using high‐speed atomic force microscopy …