Multifunctional roles and pharmacological potential of β-sitosterol: Emerging evidence toward clinical applications
Currently, available therapeutic medications are both costly as well as not entirely promising
in terms of potency. So, new candidates from natural resources are of research interest to …
in terms of potency. So, new candidates from natural resources are of research interest to …
Emerging diversity in lipid–protein interactions
Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable
membrane environment for proteins to being embedded in to detailed roles in complicated …
membrane environment for proteins to being embedded in to detailed roles in complicated …
Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity
G protein–coupled receptors (GPCRs) are critical regulators of cellular function acting via
heterotrimeric G proteins as their primary transducers with individual GPCRs capable of …
heterotrimeric G proteins as their primary transducers with individual GPCRs capable of …
Predictable cholesterol binding sites in GPCRs lack consensus motifs
A rich diversity of transmembrane G protein-coupled receptors (GPCRs) are used by
eukaryotes to sense physical and chemical signals. In humans alone, 800 GPCRs comprise …
eukaryotes to sense physical and chemical signals. In humans alone, 800 GPCRs comprise …
Direct interrogation of context-dependent GPCR activity with a universal biosensor platform
G protein-coupled receptors (GPCRs) are the largest family of druggable proteins encoded
in the human genome, but progress in understanding and targeting them is hindered by the …
in the human genome, but progress in understanding and targeting them is hindered by the …
Allosteric regulation of G-protein-coupled receptors: from diversity of molecular mechanisms to multiple allosteric sites and their ligands
AO Shpakov - International Journal of Molecular Sciences, 2023 - mdpi.com
Allosteric regulation is critical for the functioning of G protein-coupled receptors (GPCRs)
and their signaling pathways. Endogenous allosteric regulators of GPCRs are simple ions …
and their signaling pathways. Endogenous allosteric regulators of GPCRs are simple ions …
Cholesterol interaction motifs in G protein‐coupled receptors: Slippery hot spots?
P Sarkar, A Chattopadhyay - Wiley Interdisciplinary Reviews …, 2020 - Wiley Online Library
G protein‐coupled receptors (GPCRs) are cell membrane associated signaling hubs that
orchestrate a multitude of cellular functions upon binding to a diverse variety of extracellular …
orchestrate a multitude of cellular functions upon binding to a diverse variety of extracellular …
Active membrane cholesterol as a physiological effector
Y Lange, TL Steck - Chemistry and physics of lipids, 2016 - Elsevier
Sterols associate preferentially with plasma membrane sphingolipids and saturated
phospholipids to form stoichiometric complexes. Cholesterol in molar excess of the capacity …
phospholipids to form stoichiometric complexes. Cholesterol in molar excess of the capacity …
Roles of cholecystokinin in the nutritional continuum. Physiology and potential therapeutics
Cholecystokinin is a gastrointestinal peptide hormone with important roles in metabolic
physiology and the maintenance of normal nutritional status, as well as potential roles in the …
physiology and the maintenance of normal nutritional status, as well as potential roles in the …
A critical analysis of molecular mechanisms underlying membrane cholesterol sensitivity of GPCRs
G protein-coupled receptors (GPCRs) are the largest and a diverse family of proteins
involved in signal transduction across biological membranes. GPCRs mediate a wide range …
involved in signal transduction across biological membranes. GPCRs mediate a wide range …