Thrombus composition and efficacy of thrombolysis and thrombectomy in acute ischemic stroke

P Jolugbo, RAS Ariëns - Stroke, 2021 - Am Heart Assoc
Thrombi retrieved from patients with acute ischemic stroke are highly heterogeneous.
Recent data suggest that thrombus composition may impact on mechanical thrombectomy …

Correlation of imaging and histopathology of thrombi in acute ischemic stroke with etiology and outcome: a systematic review

W Brinjikji, S Duffy, A Burrows, W Hacke… - Journal of …, 2017 - jnis.bmj.com
Background and purpose Studying the imaging and histopathologic characteristics of
thrombi in ischemic stroke could provide insights into stroke etiology and ideal treatment …

Structural analysis of ischemic stroke thrombi: histological indications for therapy resistance

S Staessens, F Denorme, O Francois… - …, 2019 - pmc.ncbi.nlm.nih.gov
Ischemic stroke is caused by a thromboembolic occlusion of cerebral arteries. Treatment is
focused on fast and efficient removal of the occluding thrombus, either via intravenous …

Histopathologic composition of cerebral thrombi of acute stroke patients is correlated with stroke subtype and thrombus attenuation

JM Niesten, IC van der Schaaf, L van Dam, A Vink… - PLoS …, 2014 - journals.plos.org
Introduction We related composition of cerebral thrombi to stroke subtype and attenuation on
non-contrast CT (NCCT) to gain more insight in etiopathogenesis and to validate thrombus …

High red blood cell composition in clots is associated with successful recanalization during intra-arterial thrombectomy

JW Shin, HS Jeong, HJ Kwon, KS Song, J Kim - PloS one, 2018 - journals.plos.org
We evaluated the composition of individual clots retrieved during intra-arterial thrombectomy
in relation to recanalization success, stroke subtype, and the presence of clot signs on initial …

Risk factors of hemorrhagic transformation in acute ischaemic stroke: A systematic review and meta-analysis

J Sun, C Lam, L Christie, C Blair, X Li… - Frontiers in …, 2023 - frontiersin.org
Background Hemorrhagic transformation (HT) following reperfusion therapies for acute
ischaemic stroke often predicts a poor prognosis. This systematic review and meta-analysis …

Stroke etiology and thrombus computed tomography characteristics in patients with acute ischemic stroke: a MR CLEAN Registry substudy

N Boodt, KCJ Compagne, BG Dutra, N Samuels… - Stroke, 2020 - Am Heart Assoc
Background and Purpose—If a relationship between stroke etiology and thrombus
computed tomography characteristics exists, assessing these characteristics in clinical …

Thrombus density predicts successful recanalization with Solitaire stent retriever thrombectomy in acute ischemic stroke

M Mokin, S Morr, SK Natarajan, N Lin… - Journal of …, 2015 - jnis.bmj.com
Background Thrombus characteristics, including Hounsfield unit (HU) value to measure
density and thrombus volume and length, can predict successful recanalization following IV …

Thrombolytic therapies for ischemic stroke: Triumphs and future challenges

A Moussaddy, AM Demchuk, MD Hill - Neuropharmacology, 2018 - Elsevier
Acute stroke therapy has significantly evolved over the last two decades. The two main
advances have been the approval of intravenous chemical thrombolysis in 1995, and the …

Hyperdense vessel sign as a potential guide for the choice of stent retriever versus contact aspiration as first-line thrombectomy strategy

MH Mohammaden, DC Haussen… - Journal of …, 2021 - jnis.bmj.com
Background The first-pass effect (FPE) has emerged as a key metric for efficacy in
mechanical thrombectomy (MT). The hyperdense vessel sign (HDVS) on non-contrast head …