How does adenosine control neuronal dysfunction and neurodegeneration?

RA Cunha - Journal of neurochemistry, 2016 - Wiley Online Library
The adenosine modulation system mostly operates through inhibitory A1 (A1R) and
facilitatory A2A receptors (A2AR) in the brain. The activity‐dependent release of adenosine …

Caffeine and adenosine

JA Ribeiro, AM Sebastiao - Journal of Alzheimer's disease, 2010 - content.iospress.com
Caffeine causes most of its biological effects via antagonizing all types of adenosine
receptors (ARs): A1, A2A, A3, and A2B and, as does adenosine, exerts effects on neurons …

[HTML][HTML] Adenosine receptors and brain diseases: neuroprotection and neurodegeneration

CV Gomes, MP Kaster, AR Tomé, PM Agostinho… - … et Biophysica Acta (BBA …, 2011 - Elsevier
Adenosine acts in parallel as a neuromodulator and as a homeostatic modulator in the
central nervous system. Its neuromodulatory role relies on a balanced activation of inhibitory …

Neuroprotection by adenosine in the brain: From A1 receptor activation to A2A receptor blockade

RA Cunha - Purinergic signalling, 2005 - Springer
Adenosine is a neuromodulator that operates via the most abundant inhibitory adenosine A
1 receptors (A 1 Rs) and the less abundant, but widespread, facilitatory A 2A Rs. It is …

Adenosine A2A receptors are essential for long-term potentiation of NMDA-EPSCs at hippocampal mossy fiber synapses

N Rebola, R Lujan, RA Cunha, C Mulle - Neuron, 2008 - cell.com
The physiological conditions under which adenosine A 2A receptors modulate synaptic
transmission are presently unclear. We show that A 2A receptors are localized …

Adenosine A2A receptors and basal ganglia physiology

SN Schiffmann, G Fisone, R Moresco, RA Cunha… - Progress in …, 2007 - Elsevier
Adenosine A2A receptors are highly enriched in the basal ganglia system. They are
predominantly expressed in enkephalin-expressing GABAergic striatopallidal neurons and …

Adenosine receptors and the central nervous system

AM Sebastiao, JA Ribeiro - Adenosine receptors in health and disease, 2009 - Springer
The adenosine receptors (ARs) in the nervous system act as a kind of “go-between” to
regulate the release of neurotransmitters (this includes all known neurotransmitters) and the …

Chronic caffeine consumption prevents memory disturbance in different animal models of memory decline

RA Cunha, PM Agostinho - Journal of Alzheimer's Disease, 2010 - content.iospress.com
Caffeine, the most widely consumed psychoactive drug, enhances attention/vigilance,
stabilizes mood, and might also independently enhance cognitive performance. Notably …

Adenosine hypothesis of schizophrenia–opportunities for pharmacotherapy

D Boison, P Singer, HY Shen, J Feldon, BK Yee - Neuropharmacology, 2012 - Elsevier
Pharmacotherapy of schizophrenia based on the dopamine hypothesis remains
unsatisfactory for the negative and cognitive symptoms of the disease. Enhancing N-methyl …

Adenosine receptors and neurological disease: neuroprotection and neurodegeneration

TW Stone, S Ceruti, MP Abbracchio - Adenosine receptors in health and …, 2009 - Springer
Adenosine receptors modulate neuronal and synaptic function in a range of ways that may
make them relevant to the occurrence, development and treatment of brain ischemic …