Neurotransmitter release is governed by proteins that have homo-logs in most types of
intracellular membrane fusion, including the Sec1/Munc18 protein Munc18-1 and the …

VPS10P-domain receptors, such as SORLA and sortilin, constitute a recently identified class
of type-1 receptors that are expressed in neurons. Family members are multifunctional …

sorLA (sorting protein-related receptor) is a type-1 membrane protein of unknown function
that is expressed in neurons. Its homology to sorting receptors that shuttle between the …

Long noncoding RNAs (lncRNAs) are typically defined as transcripts longer than 200
nucleotides. lncRNAs can regulate gene expression at epigenetic, transcriptional, and …

Recent studies indicated that sortilin-related receptor 1 (SORL1) is a risk gene for late-onset
Alzheimer's disease (AD), although its role in the aetiology and/or progression of this …

Trafficking and proteolytic processing of amyloid precursor protein (APP) have been the
focus of numerous investigations in the past two decades, since the identification of Aβ as …

Epidemiological evidence suggests that long term treatment with hydroxymethylglutaryl-CoA
reductase inhibitors, or statins, decreases the risk for developing Alzheimer disease (AD) …

SorLA has been recognized as a novel sorting receptor that regulates trafficking and
processing of the amyloid precursor protein (APP) and that represents a significant risk …

Background Statins are widely used cholesterol-lowering drugs that act by inhibiting
HMGCoA reductase, the rate-limiting enzyme in cholesterol biosynthesis. Recent evidence …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder. AD is characterized
by the production and aggregation of beta-amyloid (Aβ) peptides, hyperphosphorylated tau …