Metabolic imaging at the single-cell scale: recent advances in mass spectrometry imaging

IS Gilmore, S Heiles, CL Pieterse - Annual review of analytical …, 2019 - annualreviews.org
There is an increasing appreciation that every cell, even of the same type, is different. This
complexity, when additionally combined with the variety of different cell types in tissue, is …

A new update of MALDI-TOF mass spectrometry in lipid research

KM Engel, P Prabutzki, J Leopold, A Nimptsch… - Progress in lipid …, 2022 - Elsevier
Matrix-assisted laser desorption and ionization (MALDI) mass spectrometry (MS) is an
indispensable tool in modern lipid research since it is fast, sensitive, tolerates sample …

Highly multiplexed immunohistochemical MALDI-MS imaging of biomarkers in tissues

G Yagnik, Z Liu, KJ Rothschild… - Journal of the American …, 2021 - ACS Publications
Immunohistochemistry (IHC) combined with fluorescence microscopy provides an important
and widely used tool for researchers and pathologists to image multiple biomarkers in tissue …

Image to insight: exploring natural products through mass spectrometry imaging

Y Dong, A Aharoni - Natural product reports, 2022 - pubs.rsc.org
Covering: 2017 to 2022 Mass spectrometry imaging (MSI) has become a mature molecular
imaging technique that is well-matched for natural product (NP) discovery. Here we present …

High spatial resolution MALDI imaging mass spectrometry of fresh-frozen bone

CJ Good, EK Neumann, CE Butrico, JE Cassat… - Analytical …, 2022 - ACS Publications
Bone and bone marrow are vital to mammalian structure, movement, and immunity. These
tissues are also commonly subjected to molecular alterations giving rise to debilitating …

MALDI mass spectrometry imaging: a potential game-changer in a modern microbiology

M Feucherolles, G Frache - Cells, 2022 - mdpi.com
Nowadays, matrix-assisted laser desorption/ionization time of flight mass spectrometry
(MALDI-TOF MS) is routinely implemented as the reference method for the swift and …

Recent advances in matrix‐assisted laser desorption/ionisation mass spectrometry imaging (MALDI‐MSI) for in situ analysis of endogenous molecules in plants

L Qin, Y Zhang, Y Liu, H He, M Han, Y Li… - Phytochemical …, 2018 - Wiley Online Library
Introduction Mass spectrometry imaging (MSI) as a label‐free and powerful imaging
technique enables in situ evaluation of a tissue metabolome and/or proteome, becoming …

Toward mass spectrometry imaging in the metabolomics scale: increasing metabolic coverage through multiple on-tissue chemical modifications

ME Dueñas, EA Larson, YJ Lee - Frontiers in Plant Science, 2019 - frontiersin.org
Exploring the metabolic differences directly on tissues is essential for the comprehensive
understanding of how multicellular organisms function. Mass spectrometry imaging (MSI) is …

Spatial analysis of lipid metabolites and expressed genes reveals tissue‐specific heterogeneity of lipid metabolism in high‐ and low‐oil Brassica napus L. seeds

S Lu, D Sturtevant, M Aziz, C Jin, Q Li… - The Plant …, 2018 - Wiley Online Library
Despite the importance of oilseeds to worldwide human nutrition, and more recently to the
production of bio‐based diesel fuels, the detailed mechanisms regulating seed oil …

High‐spatial resolution mass spectrometry imaging: Toward single cell metabolomics in plant tissues

RL Hansen, YJ Lee - The Chemical Record, 2018 - Wiley Online Library
Mass spectrometry imaging (MSI) is a powerful tool that has advanced our understanding of
complex biological processes by enabling unprecedented details of metabolic biology to be …