D-galactose-induced liver aging model: Its underlying mechanisms and potential therapeutic interventions

KF Azman, A Safdar, R Zakaria - Experimental Gerontology, 2021 - Elsevier
Aging is associated with a variety of morphological and functional changes in the liver.
Oxidative stress and inflammation are now widely accepted as the main mechanisms …

Relevance of endoplasmic reticulum and mitochondria interactions in age-associated diseases

A Gil-Hernández, A Silva-Palacios - Ageing Research Reviews, 2020 - Elsevier
Although the elixir of youth remains in the darkness, medical and scientific advances have
succeeded in increasing human longevity; however, the predisposition to disease and its …

Trehalose attenuates testicular aging by activating autophagy and improving mitochondrial quality

H Xi, W Shan, M Li, Z Wang, Y Li - Andrology, 2024 - Wiley Online Library
Background Reproductive aging can adversely affect male fertility and the health of
offspring. The aging process is accompanied by impaired autophagy. Recent studies have …

Is galactose a hormetic sugar? An exploratory study of the rat hippocampal redox regulatory network

J Homolak, A Babic Perhoc, A Knezovic… - Molecular Nutrition & …, 2021 - Wiley Online Library
Scope Galactose, a ubiquitous monosaccharide with incompletely understood physiology is
often exploited for inducing oxidative‐stress mediated aging in animals. Recent research …

[HTML][HTML] Role of soy isoflavone in preventing aging changes in rat testis: biochemical and histological studies

TM Al-Shaikh - Saudi Journal of Biological Sciences, 2022 - Elsevier
Testicular function and structure harmed by ageing. Goal of this research was to assess
preventive actions of soy isoflavone oral administration for 8 weeks on testes of old male …

[HTML][HTML] Integrative analysis of the transcriptome and metabolome reveals the importance of hepatokine FGF21 in liver aging

W Wang, J Qian, M Shang, Y Qiao, J Huang, X Gao… - Genes & …, 2024 - Elsevier
Aging is a contributor to liver disease. Hence, the concept of liver aging has become
prominent and has attracted considerable interest, but its underlying mechanism remains …

Is galactose a hormetic sugar? Evidence from rat hippocampal redox regulatory network

J Homolak, PA Babic, A Knezovic, I Kodvanj, D Virag… - BioRxiv, 2021 - biorxiv.org
Galactose is a ubiquitous simple monosaccharide with yet incompletely understood
biochemical and physiological role. Most of what we currently know about galactose is …

Patofiziološke promjene probavnog sustava u životinjskim modelima Alzheimerove i Parkinsonove bolesti

J Homolak - 2023 - repozitorij.mef.unizg.hr
Alzheimerova (AB) i Parkinsonova bolest (PB) najučestalije su neurodegenerativne bolesti s
nerazjašnjenom etiopatogenezom, a istraživanja upućuju na važnu ulogu probavnog …

[PDF][PDF] Imidazole derivative improves antioxidant status and causes differential alteration of redox-status in Drosophila melanogaster

ET OLUWAYEMI, OJ AWAKAN, AO ESEOLA… - … International Journal of …, 2022 - iasj.net
This study investigated the toxicity of a new imidazole compound, 1-(1, 4, 5-triphenyl-1H-
imidazol-2-yl)-naphthalen-2-ol, through the evaluation of selected oxidative stress markers …

[PDF][PDF] Separating science from science fiction: Can a non-existent enzyme be a primary driver of pathophysiological processes in galactose-induced rodent models of …

J Homolak, I Kodvanj, K Toljan, AB Perhoc, D Virag… - researchgate.net
Separating science from science fiction: Can a non-existent enzyme be a primary driver of
pathophysiological processes in galact Page 1 1 Separating science from science fiction: Can a …