The landscape of mRNA nanomedicine

X Huang, N Kong, X Zhang, Y Cao, R Langer, W Tao - Nature Medicine, 2022 - nature.com
Messenger RNA (mRNA) is an emerging class of therapeutic agent for the prevention and
treatment of a wide range of diseases. The recent success of the two highly efficacious …

mRNA-based cancer therapeutics

C Liu, Q Shi, X Huang, S Koo, N Kong, W Tao - Nature Reviews Cancer, 2023 - nature.com
Due to the fact that mRNA technology allows the production of diverse vaccines and
treatments in a shorter time frame and with reduced expense compared to conventional …

mRNA-based therapeutics: powerful and versatile tools to combat diseases

S Qin, X Tang, Y Chen, K Chen, N Fan… - Signal transduction and …, 2022 - nature.com
The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide
range of incurable diseases. Recent rapid advances in biotechnology and molecular …

An ionizable lipid toolbox for RNA delivery

X Han, H Zhang, K Butowska, KL Swingle… - Nature …, 2021 - nature.com
Recent years have witnessed incredible growth in RNA therapeutics, which has benefited
significantly from decades of research on lipid nanoparticles, specifically its key component …

Lipid nanoparticle (LNP) enables mRNA delivery for cancer therapy

Y Zong, Y Lin, T Wei, Q Cheng - Advanced Materials, 2023 - Wiley Online Library
Messenger RNA (mRNA) has received great attention in the prevention and treatment of
various diseases due to the success of coronavirus disease 2019 (COVID‐19) mRNA …

[HTML][HTML] Lipid nanoparticles for mRNA delivery

X Hou, T Zaks, R Langer, Y Dong - Nature Reviews Materials, 2021 - nature.com
Messenger RNA (mRNA) has emerged as a new category of therapeutic agent to prevent
and treat various diseases. To function in vivo, mRNA requires safe, effective and stable …

Lipids and lipid derivatives for RNA delivery

Y Zhang, C Sun, C Wang, KE Jankovic… - Chemical reviews, 2021 - ACS Publications
RNA-based therapeutics have shown great promise in treating a broad spectrum of
diseases through various mechanisms including knockdown of pathological genes …

Biomedicine meets Fenton chemistry

Z Tang, P Zhao, H Wang, Y Liu, W Bu - Chemical reviews, 2021 - ACS Publications
Since the first connection between Fenton chemistry and biomedicine, numerous studies
have been presented in this field. Comprehensive presentation of the guidance from Fenton …

Nanomaterial delivery systems for mRNA vaccines

MD Buschmann, MJ Carrasco, S Alishetty, M Paige… - Vaccines, 2021 - mdpi.com
The recent success of mRNA vaccines in SARS-CoV-2 clinical trials is in part due to the
development of lipid nanoparticle delivery systems that not only efficiently express the …

Emerging mRNA technologies: delivery strategies and biomedical applications

Y Xiao, Z Tang, X Huang, W Chen, J Zhou… - Chemical Society …, 2022 - pubs.rsc.org
The great success achieved by the two highly-effective messenger RNA (mRNA) vaccines
during the COVID-19 pandemic highlights the great potential of mRNA technology. Through …