Recombinant interferon‐α (IFN‐α) was approved by regulatory agencies in many countries
in 1986. As the first biotherapeutic approved, IFN‐α paved the way for the development of …

▪ Abstract The Class 2 α-helical cytokines consist of interleukin-10 (IL-10), IL-19, IL-20, IL-22,
IL-24 (Mda-7), and IL-26, interferons (IFN-α,-β,-ε,-κ,-ω,-δ,-τ, and-γ) and interferon-like …

To replicate in vivo, viruses must circumvent cellular antiviral defense mechanisms,
including those induced by the interferons (IFNs). Here we demonstrate that simian virus 5 …

A cDNA coding for the human interferon a receptor has been cloned using a gene transfer
approach. This consists of transferring human DNA to mouse cells and selecting for cells …

Background The human α-interferon (huIFN-α) family displays broad spectrum antiviral,
antiproliferative and immunomodulatory activities on a variety of cell types. The diverse …

Recent results indicate that coherent models of how multiple interferons (IFN) are
recognized and signal selectively through a common receptor are now feasible. A proposal …

Cytokines affecting mononuclear phagocytes were screened for activation of human
macrophages to secrete H2O2 and kill toxoplasmas. In contrast to recombinant interferon …

Cytosolic viral RNA recognition by the helicases RIG-I and MDA5 is considered the major
pathway for IFN-α/β induction in response to RNA viruses. However, other cytoplasmic RNA …

Genomic and cDNA clones corresponding to 9-27, a member of the human 1-8 gene family
highly inducible by alpha-and gamma-interferons (IFNs), have been isolated and …

Publisher Summary This chapter discusses the types, effects, and properties of interferons
(IFN). Interferons are classified into two types, I and II, on the basis of distinct biological …