Bioavailability of glucosinolates and their breakdown products: impact of processing

FJ Barba, N Nikmaram, S Roohinejad, A Khelfa… - Frontiers in …, 2016 - frontiersin.org
Glucosinolates are a large group of plant secondary metabolites with nutritional effects, and
are mainly found in cruciferous plants. After ingestion, glucosinolates could be partially …

Bio-protective effects of glucosinolates–A review

AP Vig, G Rampal, TS Thind, S Arora - LWT-Food Science and Technology, 2009 - Elsevier
Glucosinolates are an important and unique class of secondary plant products containing β-
D-thioglucose and sulphonated oxime moieties. These include thioglucosides …

Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by β-phenylethyl isothiocyanate

D Trachootham, Y Zhou, H Zhang, Y Demizu, Z Chen… - Cancer cell, 2006 - cell.com
Reactive oxygen species (ROS) stimulate cell proliferation and induce genetic instability,
and their increase in cancer cells is often viewed as an adverse event. Here, we show that …

Are isothiocyanates potential anti-cancer drugs?

X Wu, Q Zhou, K Xu - Acta Pharmacologica Sinica, 2009 - nature.com
Isothiocyanates are naturally occurring small molecules that are formed from glucosinolate
precursors of cruciferous vegetables. Many isothiocyanates, both natural and synthetic …

A Comparative Study of Flavonoid Compounds, Vitamin C, and Antioxidant Properties of Baby Leaf Brassicaceae Species

A Martínez-Sánchez, A Gil-Izquierdo… - Journal of agricultural …, 2008 - ACS Publications
A comparative study of antioxidant compounds, flavonoids and vitamin C, and also
antioxidant activity was carried out in four species of Brassicaceae vegetables used for …

Keap calm, and carry on covalently

AJ Wilson, JK Kerns, JF Callahan… - Journal of medicinal …, 2013 - ACS Publications
The Nrf2–Keap1 system plays a major role in cellular defense against oxidative stress. Upon
exposure to electrophiles, the cysteine-rich protein Keap1 is covalently modified, and it is …

β‐Phenethyl Isothiocyanate Induces Cell Death in Human Osteosarcoma through Altering Iron Metabolism, Disturbing the Redox Balance, and Activating the MAPK …

H Lv, C Zhen, J Liu, P Shang - Oxidative Medicine and Cellular …, 2020 - Wiley Online Library
Osteosarcoma is the most common primary malignancy of the skeleton in children and
adults. The outcomes of people with osteosarcomas are unsatisfied. β‐Phenethyl …

Heterocyclic scaffolds as promising anticancer agents against tumours of the central nervous system: Exploring the scope of indole and carbazole derivatives

C Sherer, TJ Snape - European journal of medicinal chemistry, 2015 - Elsevier
Tumours of the central nervous system are intrinsically more dangerous than tumours at
other sites, and in particular, brain tumours are responsible for 3% of cancer deaths in the …

Glutathione in ovarian cancer: a double-edged sword

SC Nunes, J Serpa - International journal of molecular sciences, 2018 - mdpi.com
Glutathione (GSH) has several roles in a cell, such as a reactive oxygen species (ROS)
scavenger, an intervenient in xenobiotics metabolism and a reservoir of cysteine. All of these …

PEITC triggers multiple forms of cell death by GSH-iron-ROS regulation in K7M2 murine osteosarcoma cells

H Lv, C Zhen, J Liu, P Shang - Acta Pharmacologica Sinica, 2020 - nature.com
Phenethyl isothiocyanate (PEITC) is an isothiocyanate that largely exists in cruciferous
vegetables and exhibits chemopreventive and chemotherapeutic potential against various …