Mechanobiology has underpinned many scientific advances in understanding how
biophysical and biomechanical cues regulate cell behavior by identifying mechanosensitive …

Adenylyl cyclases (ACs) catalyze the conversion of ATP to the ubiquitous second
messenger cAMP. Mammals possess nine isoforms of transmembrane ACs, dubbed AC1–9 …

Large bone defects are a major global health concern. Bone tissue engineering (BTE) is the
most promising alternative to avoid the drawbacks of autograft and allograft bone …

Mesenchymal stem cells (MSCs) from adult tissues are promising candidates for
personalized cell therapy and tissue engineering. Significant progress was achieved in our …

Treatment of bone defects remains a challenge in the clinic. Artificial bone grafts are the
most promising alternative to autologous bone grafting. However, one of the limiting factors …

Osteoporosis is a common bone metabolic disease in postmenopausal women, diabetic
patients and obese patients and is characterized by an imbalance in bone formation and …

The repair of critical bone defects remains challenging worldwide. Three canonical pillars
(biomaterial scaffolds, bioactive molecules, and stem cells) of bone tissue engineering have …

Osteoarthritis (OA) is one of the most prevalent joint disorders associated with the
degradation of articular cartilage and an abnormal mechanical microenvironment …

Primary cilia and associated intraflagellar transport are essential for skeletal development,
joint homeostasis, and the response to mechanical stimuli, although the mechanisms remain …

Estrogen deficiency during post-menopausal osteoporosis leads to osteoclastogenesis and
bone loss. Increased pro-osteoclastogenic signalling (RANKL/OPG) by osteocytes occurs …