Intramolecular four-way junctions are structures present during homologous recombination,
repair of double stranded DNA breaks, and integron recombination. Because of the wide …

We report that Cy3 undergoes triple helix conformation-specific blinking in DNA. Blinking
patterns were affected by the stabilization of the Hoogsteen base-pair, suggesting that not …

Intramolecular three-way junctions are commonly found in both DNA and RNA. These
structures are functionally relevant in ribozymes, riboswitches, rRNA, and during replication …

Pseudoknots have diverse and important roles in many biological functions. We used a
combination of UV spectroscopy and differential scanning calorimetry to investigate the …

Nucleic acids serve many biological functions beyond information storage. These functions
depend on the ability of a nucleic acid to adopt a specific spatial configuration in a process …

We use a variety of biophysical techniques to determine thermodynamic profiles, including
hydration, for the unfolding of DNA stem-loop motifs (hairpin, a three-way junction and a …

The folding of mRNA sequences into secondary/tertiary structures plays an important role in
RNA and DNA function and expression. Disruption of these structures can potentially be …

The main focus is to further our understanding of the physico-chemical properties of unusual
DNA structures. We designed a set of stem-loop DNA molecules to mimic a common motif of …

Pseudoknots belong to an RNA structural motif that has significant roles in the biological
function of RNA. An example is ribosomal frameshifting; in this mechanism, the formation of …

The preQ1 riboswitch aptamer domain is very dynamic in its unbound state with the ability to
form multiple structures: a hairpin, kissing hairpins, and pseudoknot-like structure. The aim …