Advances in TRP channel drug discovery: from target validation to clinical studies
AP Koivisto, MG Belvisi, R Gaudet… - Nature reviews Drug …, 2022 - nature.com
Transient receptor potential (TRP) channels are multifunctional signalling molecules with
many roles in sensory perception and cellular physiology. Therefore, it is not surprising that …
many roles in sensory perception and cellular physiology. Therefore, it is not surprising that …
TRP (transient receptor potential) ion channel family: Structures, biological functions and therapeutic interventions for diseases
Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
Internal senses of the vagus nerve
SL Prescott, SD Liberles - Neuron, 2022 - cell.com
The vagus nerve is an indispensable body-brain connection that controls vital aspects of
autonomic physiology like breathing, heart rate, blood pressure, and gut motility, reflexes …
autonomic physiology like breathing, heart rate, blood pressure, and gut motility, reflexes …
Roles of inflammation, neurogenic inflammation, and neuroinflammation in pain
Inflammation is the body's response to injury and infection, involving a complex biological
response of the somatosensory, immune, autonomic, and vascular systems. Inflammatory …
response of the somatosensory, immune, autonomic, and vascular systems. Inflammatory …
[HTML][HTML] TRP channels in thermosensation
M Kashio, M Tominaga - Current Opinion in Neurobiology, 2022 - Elsevier
The ability to sense external temperature is assumed by somatosensory neurons, in which
temperature information is converted to neural activity by afferent input to the central nervous …
temperature information is converted to neural activity by afferent input to the central nervous …
[HTML][HTML] Enterochromaffin cells are gut chemosensors that couple to sensory neural pathways
Dietary, microbial, and inflammatory factors modulate the gut-brain axis and influence
physiological processes ranging from metabolism to cognition. The gut epithelium is a …
physiological processes ranging from metabolism to cognition. The gut epithelium is a …
[HTML][HTML] Mammalian transient receptor potential TRPA1 channels: from structure to disease
K Talavera, JB Startek, J Alvarez-Collazo… - Physiological …, 2020 - journals.physiology.org
The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …
cation channels remarkably conserved through the animal kingdom. Mammals have only …
Mechanically activated ion channels
Mechanotransduction, the conversion of physical forces into biochemical signals, is
essential for various physiological processes such as the conscious sensations of touch and …
essential for various physiological processes such as the conscious sensations of touch and …
Transient receptor potential (TRP) channels
A Samanta, TET Hughes… - … complexes: Structure and …, 2018 - Springer
Abstract Transient Receptor Potential (TRP) channels are evolutionarily conserved integral
membrane proteins. The mammalian TRP superfamily of ion channels consists of 28 cation …
membrane proteins. The mammalian TRP superfamily of ion channels consists of 28 cation …
Structure of the TRPA1 ion channel suggests regulatory mechanisms
The TRPA1 ion channel (also known as the wasabi receptor) is a detector of noxious
chemical agents encountered in our environment or produced endogenously during tissue …
chemical agents encountered in our environment or produced endogenously during tissue …