The excess of saturated free fatty acids, such as palmitic acid, that induces lipotoxicity in
hepatocytes, has been implicated in the development of non-alcoholic fatty liver disease …

Purpose To investigate hypertrophic signalling after a single bout of low-load resistance
exercise with and without blood flow restriction (BFR). Methods Seven subjects performed …

Skeletal muscle plays a major role in the control of whole body glucose disposal in response
to insulin stimulus. Excessive supply of fatty acids to this tissue triggers cellular and …

In Alzheimer's disease (AD), reactive astrocytes produce extracellular vesicles (EVs) that
affect mitochondria in neurons. Here, we show that Aβ-induced generation of the …

Exerkines are soluble factors secreted by exercised muscles, mimicking the effects of
exercise in various organs, including the muscle itself. Lumican is reportedly secreted from …

A low metabolic flexibility to lipid (MetF-lip) in skeletal muscle may promote ectopic lipid
accumulation, thus inducing metabolic disturbances. We aimed to determine the association …

Toll-like receptors (TLRs) play an important role in regulating muscle regeneration and
angiogenesis in response to ischemia. TLR2 knockout mice exhibit pronounced skeletal …

We have previously shown that im administration of bacterially expressed murine histidyl-
tRNA synthetase (HRS) triggers florid muscle inflammation (relative to appropriate control …

Cellular signaling circuitry in eukaryotes can be studied by analyzing the regulation of
protein phosphorylation and its impact on downstream mechanisms leading to a phenotype …

摘要背景: 近年来, 骨骼肌损伤的发生率越来越高, 但骨骼肌本身的修复能力有限,
研究骨骼肌损伤修复的分子机制对于骨骼肌损伤的治疗具有积极的作用. 目的: 探讨microRNA …