Glaucoma is a group of diseases characterized by progressive optic nerve degeneration that
results in visual field loss and irreversible blindness. A crucial element in the …

This article reviews findings up to the end of 1997 about the inducible transcription factors
(ITFs) c-Jun, JunB, JunD, c-Fos, FosB, Fra-1, Fra-2, Krox-20 (Egr-2) and Krox-24 (NGFI-A …

purpose. In both animal model systems and in human glaucoma, retinal ganglion cells
(RGCs) die by apoptosis. To understand how RGC apoptosis is initiated in these systems …

Activation of microglia commonly occurs in response to a wide variety of pathological stimuli
including trauma, axotomy, ischemia, and degeneration in the CNS. In the retina, prolonged …

In this study, we demonstrate that:(i) injection of an adenovirus (Ad) vector containing the
brain-derived neurotrophic factor (BDNF) gene (Ad. BDNF) into the vitreous chamber of …

Brain-derived neurotrophic factor (BDNF) has a unique role in the neuronal development,
differentiation, and survival in the developing and adult nervous system. A common single …

Glaucoma is a disease in which retinal ganglion cells (RGCs) die leading ultimately to
blindness. Over the past decade and a half, information has begun to emerge regarding …

Injury-induced downregulation of neurotrophin receptors may limit the response of neurons
to trophic factors, compromising their ability to survive. We tested this hypothesis in a model …

Expression of the neurotrophin brain-derived neurotrophic factor (BDNF) and its receptor
trkB in the ganglion cell layer of the Xenopus retina during retinal ganglion cell (RGC) …

purpose. To determine whether brain-derived neurotrophic factor (BDNF), a neuroprotectant
in the small rat eye, might also serve as an effective neuroprotectant in larger vertebrate …