The hydrolysis of a minor membrane phospholipid, phosphatidylinositol 4, 5-bisphosphate
(PIP2), 1 by a specific phospholipase C (PLC) is one of the earliest key events in the …

Biochi~ic~a Page 1 ELSEVIER Biochimica et Biophysica Acta 1242 (1995) 99-114 i BB
Biochi~ic~a et Biophysica A~ta Phosphoinositide-specific phospholipase C and mitogenic …

The phospholipase C (PLC)-β isozymes differ from the PLC-γ and PLC-γ isozymes in that
they possess a long COOH-terminal sequence downstream of their catalytic domain, are …

Regulation of Ca2+ in the nucleus is a debated issue, essentially due to the presence in the
envelope of the pores, which are large enough to permit the passive traffic of small …

Phosphoinositide signaling resides in the nucleus, and among the enzymes of the cycle,
phospholipase C (PLC) appears as the key element both in Saccharomyces cerevisiaeand …

Phospholipase Cγ1 (PLC-γ1) hydrolyses phosphatidylinositol-4, 5-bisphosphate to the
second messengers inositol-1, 4, 5-trisphosphate and diacylglycerol. PLC-γ1 also has …

The present review aims to systematically and critically analyze the current knowledge on
phospholipases and their role in physiological and pathological mineralization undertaken …

The interleukin 1 (ILl) family of proteins currently comprises ILl or, ILl/3 and the ILl receptor
antagonist, IL1RA. The biological activities of ILl are shared by ILla and ILl/3, with IL1RA …

Diverse methodologies, ranging from activity measurements in various nuclear subfractions
to electron microscopy, have been used to demonstrate and establish that many of the key …

Protein kinase C (PKC) is activated at the nucleus during the G 2 phase of cell cycle, where
it is required for mitosis. However, the mechanisms controlling cell cycle-dependent …