Quality control in the endoplasmic reticulum: crosstalk between ERAD and UPR pathways
Endoplasmic reticulum (ER)-associated degradation (ERAD) and the unfolded protein
response (UPR) are two key quality-control machineries in the cell. ERAD is responsible for …
response (UPR) are two key quality-control machineries in the cell. ERAD is responsible for …
New insights into the physiological role of endoplasmic reticulum-associated degradation
Many human diseases are associated with mutations causing protein misfolding and
aggregation in the endoplasmic reticulum (ER). ER-associated degradation (ERAD) is a …
aggregation in the endoplasmic reticulum (ER). ER-associated degradation (ERAD) is a …
SEL1L–HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool
Stimulator of interferon genes (STING) orchestrates the production of proinflammatory
cytokines in response to cytosolic double-stranded DNA; however, the pathophysiological …
cytokines in response to cytosolic double-stranded DNA; however, the pathophysiological …
Biallelic Cys141Tyr variant of SEL1L is associated with neurodevelopmental disorders, agammaglobulinemia, and premature death
Suppressor of lin-12-like–HMG-CoA reductase degradation 1 (SEL1L-HRD1) ER-
associated degradation (ERAD) plays a critical role in many physiological processes in …
associated degradation (ERAD) plays a critical role in many physiological processes in …
Hypomorphic variants of SEL1L-HRD1 ER-associated degradation are associated with neurodevelopmental disorders
Recent studies using cell type–specific knockout mouse models have improved our
understanding of the pathophysiological relevance of suppressor of lin-12-like–HMG-CoA …
understanding of the pathophysiological relevance of suppressor of lin-12-like–HMG-CoA …
Intestinal dysbiosis featuring abundance of Ruminococcus gnavus associates with allergic diseases in infants
HH Chua, HC Chou, YL Tung, BL Chiang, CC Liao… - Gastroenterology, 2018 - Elsevier
Background & Aims Dysbiosis of the intestinal microbiota has been associated with
development of allergies in infants. However, it is not clear what microbes might contribute to …
development of allergies in infants. However, it is not clear what microbes might contribute to …
Endoplasmic reticulum–associated degradation regulates mitochondrial dynamics in brown adipocytes
Z Zhou, M Torres, H Sha, CJ Halbrook… - Science, 2020 - science.org
The endoplasmic reticulum (ER) engages mitochondria at specialized ER domains known
as mitochondria-associated membranes (MAMs). Here, we used three-dimensional high …
as mitochondria-associated membranes (MAMs). Here, we used three-dimensional high …
Proteomic screens of SEL1L-HRD1 ER-associated degradation substrates reveal its role in glycosylphosphatidylinositol-anchored protein biogenesis
Endoplasmic reticulum-associated degradation (ERAD) plays indispensable roles in many
physiological processes; however, the nature of endogenous substrates remains largely …
physiological processes; however, the nature of endogenous substrates remains largely …
ER-associated degradation in health and disease–from substrate to organism
A Bhattacharya, L Qi - Journal of Cell Science, 2019 - journals.biologists.com
The recent literature has revolutionized our view on the vital importance of endoplasmic
reticulum (ER)-associated degradation (ERAD) in health and disease. Suppressor/enhancer …
reticulum (ER)-associated degradation (ERAD) in health and disease. Suppressor/enhancer …
SEL1L-HRD1 interaction is required to form a functional HRD1 ERAD complex
Abstract The SEL1L-HRD1 protein complex represents the most conserved branch of
endoplasmic reticulum (ER)-associated degradation (ERAD). Despite recent advances in …
endoplasmic reticulum (ER)-associated degradation (ERAD). Despite recent advances in …