Native mass spectrometry (MS) involves the analysis and characterization of
macromolecules, predominantly intact proteins and protein complexes, whereby as much as …

In biology, it can be argued that if the genome contains the script for a cell's life cycle, then
the proteome constitutes an ensemble cast of actors that brings these instructions to life …

The high-resolution structures of ribosomal subunits published in 2000 have revolutionized
the field of protein translation. They facilitated the determination and interpretation of …

Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …

The versatile combination of affinity purification and mass spectrometry (AP–MS) has
recently been applied to the detailed characterization of many protein complexes and large …

The growing number of applications to determine the stoichiometry, interactions and even
subunit architecture of protein complexes from mass spectra suggests that some general …

Investigation of the structure, assembly and function of protein–nucleic acid macromolecular
machines requires multidimensional molecular and structural biology approaches. We …

Proteomic studies have yielded detailed lists of the proteins present in a cell. Comparatively
little is known, however, about how these proteins interact and are spatially arranged within …

How does the development of mass spectrometry (MS) for the study of protein complexes,
intact in the gas phase, contribute to the twin fields of genomics and proteomics? Foremost …

Native mass spectrometry (MS) is aimed at preserving and determining the native structure,
composition, and stoichiometry of biomolecules and their complexes from solution after they …