Fucosylation is one of the most common modifications involving oligosaccharides on
glycoproteins or glycolipids. Fucosylation comprises the attachment of a fucose residue to N …

Glycosylation is one of the most common post‐translational modifications, and
approximately 50% of all proteins are presumed to be glycosylated in eukaryotes. Branched …

Protein glycosylation is an important posttranslational process, which regulates protein
folding and functional expression. Studies have shown that abnormal glycosylation in tumor …

BACKGROUND & AIMS: The role of trypsinogen activation in the pathogenesis of acute
pancreatitis (AP) has not been clearly established. METHODS: We generated and …

Vaginal dysbiosis often occurs in patients with cervical cancer. The fucosylation of mucosal
epithelial cells is closely related to microbial colonization, and play an important role in …

Glycosylation changes are key molecular events in tumorigenesis, progression and
glycosyltransferases play a vital role in the this process. FUT8 belongs to the …

Most of the membrane molecules involved in immune response are glycosylated. N-glycans
linked to asparagine (Asn) of immune molecules contribute to the protein conformation …

Epidermal growth factor receptor (EGFR) is a heavily glycosylated transmembrane receptor
tyrosine kinase. Upon EGF-binding, EGFR undergoes conformational changes to dimerize …

Abstract Mammalian α1, 6-fucosyltransferase (FUT8) catalyses the transfer of a fucose
residue from a donor substrate, guanosine 5′-diphosphate-β-l-fucose to the reducing …

Immunotherapy is revolutionizing health care, with the majority of high impact “drugs”
approved in the past decade falling into this category of therapy. Despite considerable …