The synucleins are a family of natively unfolded (or intrinsically unstructured) proteins
consisting of α-, β-, and γ-synuclein involved in neurodegenerative diseases and cancer …

α-Synuclein (αS) is a small, unstructured, presynaptic protein expressed in the brain. Its
aggregated form is a major component of Lewy bodies, the large proteinaceous deposits in …

Summary α-synuclein, β-synuclein, and γ-synuclein are abundantly expressed proteins in
the vertebrate nervous system. α-synuclein functions in neurotransmitter release by binding …

Novel work in adult zebrafish, Danio rerio, to recapitulate human neurodegenerative
disease has proven useful in both pharmaceutical development and research on genetic …

Parkinson's disease (PD) is characterized by cell loss in the substantia nigra and the
presence of alpha-synuclein (α-syn)-containing neuronal Lewy bodies. While α-syn has …

Synucleins comprise a family of small proteins highly expressed in the nervous system of
vertebrates and involved in various intraneuronal processes. The malfunction of alpha …

Simple Summary Emerging evidence on synucleins and astrocytes warrants closer
inspection of their functional relationship. The expression and release of synucleins from the …

Parkinson's disease (PD) is one of the key neurodegenerative disorders caused by a
dopamine deficiency in the striatum due to the death of dopaminergic (DA) neurons of the …

The abnormal accumulation of α-synuclein in the brain is a common feature of Parkinson's
disease (PD), PD dementia (PDD), dementia with Lewy bodies (DLB) and multiple system …

Alpha-synuclein (aSyn) plays a central role in Parkinson's disease (PD) and has been
extensively studied in the brain. This protein is part of the synuclein family, which is also …