Lysosomes are membrane‐bound intracellular organelles that receive macromolecules
delivered by endocytosis, phagocytosis, and autophagy for degradation and recycling. Over …

In the past years, several lines of evidence have shown that cell cycle regulatory proteins
also can modulate metabolic processes. The transcription factor E2F1 is a central player …

Blood-brain barrier (BBB) damage can be a result of central nervous system (CNS) diseases
and may be a cause of CNS deterioration. However, there are still many unknowns …

Cancer‐associated fibroblasts (CAFs) as a predominant cell component in the tumour
microenvironment (TME) play an essential role in tumour progression. Our earlier studies …

The mechanistic target of rapamycin complex 1 (mTORC1) coordinates cellular growth and
metabolism with environmental inputs to ensure that cells grow only under favourable …

Recent developments in lysosome biology have transformed our view of lysosomes from
static garbage disposals that can also act as suicide bags to decidedly dynamic multirole …

The NAD+-dependent deacetylase Sirtuin 1 (SIRT1) is down-regulated in triple-negative
breast cancer. To determine the mechanistic basis by which reduced SIRT1 expression …

Glucose is a major requirement for biological life. Its concentration is constantly sensed at
the cellular level, allowing for adequate responses to any changes of glucose availability …

Cancer cells generate large quantities of cytoplasmic protons as byproducts of aberrantly
activated aerobic glycolysis and lactate fermentation. To avoid potentially detrimental …

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Introduction: Cancer is an intricate disorder/dysfunction of cells that can be defined as a …