The perception that intracellular lipolysis is a straightforward process that releases fatty
acids from fat stores in adipose tissue to generate energy has experienced major revisions …

Background Lipid droplet (LD) is a metabolically active organelle, which changes
dynamically with the metabolic state and energy requirements of cells. Proteins that either …

Insulin-producing pancreatic β-cells are central to glucose homeostasis, and their failure is a
principal driver of diabetes development. To preserve optimal health β-cells must withstand …

Obesity with its associated complications represents a social, economic and health problem
of utmost importance worldwide. Specifically, obese patients carry a significantly higher risk …

During development of type 2 diabetes (T2D), excessive nutritional load is thought to expose
pancreatic islets to toxic effects of lipids and reduce β-cell function and mass. However …

The hypoxic state of the tumor microenvironment leads to reprogramming lipid metabolism
in tumor cells. Adipose triglyceride lipase, also known as patatin-like phospholipase …

Neutrophils are an essential part of the innate immune system, playing a critical role in the
control of infectious diseases, maintenance of tissue homeostasis and regulation of …

Background and objective Pancreatic fat is a form of ectopic fat. Lipid droplets (LDs) are also
observed in β cells; however, the pathophysiological significance, especially for β cell …

Pancreatic islets are vital endocrine regulators of systemic metabolism, and recent
investigations have increasingly focused on understanding human islet biology. Studies of …

Ectopic fat is found in liver, muscle, and kidney and is known to accumulate as visceral fat. In
recent years, ectopic fat has also been observed in the pancreas, and it has been said that …