The 2‐Pyridyl Problem: Challenging Nucleophiles in Cross‐Coupling Arylations

XAF Cook, A de Gombert, J McKnight… - Angewandte …, 2021 - Wiley Online Library
Azine‐containing biaryls are ubiquitous scaffolds in many areas of chemistry, and efficient
methods for their synthesis are continually desired. Pyridine rings are prominent amongst …

C–H Functionalization of Pyridines via Oxazino Pyridine Intermediates: Switching to para-Selectivity under Acidic Conditions

H Cao, D Bhattacharya, Q Cheng… - Journal of the American …, 2023 - ACS Publications
para-Selective C–H functionalization of pyridines holds a significant value but remains
underdeveloped. Site-switchable C–H functionalization of pyridines under easily tunable …

Pyridine C (sp2)–H bond functionalization under transition-metal and rare earth metal catalysis

H Sindhe, MM Reddy, K Rajkumar… - Beilstein Journal of …, 2023 - beilstein-journals.org
Pyridine is a crucial heterocyclic scaffold that is widely found in organic chemistry,
medicines, natural products, and functional materials. In spite of the discovery of several …

Copper-Mediated and Palladium-Catalyzed Cross-Coupling of Indoles and N-Methylpyridinium Salts: A Practical Way to Prepare 3-(Pyridin-2-yl)indoles

J Tang, S Li, J Zhang, M Yan, Y Shi, X Zheng… - Organic …, 2023 - ACS Publications
Herein, a Pd/Cu bimetallic-catalyzed direct C–H heteroarylation of pyridines via the
traceless protecting group strategy is described. A series of N-methyl-activated pyridines …

Ag/Pd Cocatalyzed Direct Arylation of Fluoroarene Derivatives with Aryl Bromides

A Panigrahi, D Whitaker, IJ Vitorica-Yrezabal… - ACS catalysis, 2020 - ACS Publications
Diverse C–H functionalizations catalyzed by Pd employ Ag (I) salts added as halide
abstractors or oxidants. Recent reports have shown that Ag can also perform the crucial C–H …

Stereodivergent synthesis of alkenylpyridines via Pd/Cu catalyzed C–H alkenylation of pyridinium salts with alkynes

W Li, J Tang, S Li, X Zheng, M Yuan, B Xu… - Organic …, 2020 - ACS Publications
The first Pd/Cu catalyzed selective C2-alkenylation of pyridines with internal alkynes has
been developed via the pyridinium salt activation strategy. Importantly, the configuration of …

Direct C–H Sulfonylimination of Pyridinium Salts

L Luo, J Tang, R Sun, W Li, X Zheng, M Yuan… - Organic …, 2022 - ACS Publications
A direct pyridinium C–H sulfonylimination has been developed for the synthesis of sulfonyl
iminopyridine derivatives with high efficiency. This transformation features the direct and …

Regioselective access to di-and trisubstituted pyridines via a metal-oxidant-solvent-free domino reaction involving 3-chloropropiophenones

AK Patel, SS Rathor, S Samanta - Organic & Biomolecular Chemistry, 2022 - pubs.rsc.org
A remarkable metal-oxidant-solvent-and base-free domino route for regioselective access to
a wide range of 2, 4-di-and 2, 3, 4/6-trisubstituted pyridines including carbo-and heterocyclic …

C6‐Selective Direct Arylation of 2‐Phenylpyridine via an Activated N‐methylpyridinium Salt: A Combined Experimental and Theoretical Study

C Yin, K Zhong, W Li, X Yang, R Sun… - Advanced Synthesis …, 2018 - Wiley Online Library
An elegant pre‐activation strategy, based on the formation of N‐methylpyridinium iodide
salts for C6‐selective direct arylation of 2‐phenylpyridines using Pd/Cu cooperative …

Transition‐Metal‐Free Regioselective Direct C2, C4 Difunctionalization and C2, C4, C6 Trifunctionalization of Pyridines

D Wang, L Xu, S Zheng, X Yang - Advanced Synthesis & …, 2022 - Wiley Online Library
This study reports the invention of di‐or trifunctionalization of readily available pyridines
(including all the pyridine substrates utilized in this paper, such as 3‐cyanopyridine and 3 …