Highlights•The review covers the self-assembly of de novo designed α-helical
peptides.•Symmetry-directed assembly of simple components leads to more-complex …

The design of modular protein logic for regulating protein function at the posttranscriptional
level is a challenge for synthetic biology. Here, we describe the design of two-input AND …

In mammalian cells, signalling pathways orchestrate cellular growth, differentiation and
survival, as well as many other processes that are essential for the proper functioning of …

Increasingly, it is possible to design peptide and protein assemblies de novo from first
principles or computationally. This approach provides new routes to functional synthetic …

Recent advances in de novo protein design have delivered a diversity of discrete de novo
protein structures and complexes. A new challenge for the field is to use these designs …

INTRODUCTION Synthetic biology applies engineering methodologies to biology to build
new functions into living cells. Through the assembly and characterization of engineered …

Abstract One-dimensional (1D) supramolecular polymers are commonly found in natural
and synthetic systems to prompt functional responses that capitalise on hierarchical …

Modules that switch protein-protein interactions on and off are essential to develop synthetic
biology; for example, to construct orthogonal signaling pathways, to control artificial protein …

De novo protein design is advancing rapidly. However, most designs are for single states.
Here we report a de novo designed peptide that forms multiple α-helical-bundle states that …

The design of completely synthetic proteins from first principles—de novo protein design—is
challenging. This is because, despite recent advances in computational protein–structure …