Alternative splicing as a source of phenotypic diversity
A major goal of evolutionary genetics is to understand the genetic processes that give rise to
phenotypic diversity in multicellular organisms. Alternative splicing generates multiple …
phenotypic diversity in multicellular organisms. Alternative splicing generates multiple …
[HTML][HTML] Alternative splicing in the mammalian nervous system: recent insights into mechanisms and functional roles
B Raj, BJ Blencowe - Neuron, 2015 - cell.com
High-throughput transcriptomic profiling approaches have revealed that alternative splicing
(AS) of precursor mRNAs, a fundamental process by which cells expand their transcriptomic …
(AS) of precursor mRNAs, a fundamental process by which cells expand their transcriptomic …
Alternative splicing during mammalian organ development
Alternative splicing (AS) is pervasive in mammalian genomes, yet cross-species
comparisons have been largely restricted to adult tissues and the functionality of most AS …
comparisons have been largely restricted to adult tissues and the functionality of most AS …
DNA methylation: conducting the orchestra from exposure to phenotype?
FAD Leenen, CP Muller, JD Turner - Clinical epigenetics, 2016 - Springer
Abstract DNA methylation, through 5-methyl-and 5-hydroxymethylcytosine (5mC and 5hmC),
is considered to be one of the principal interfaces between the genome and our …
is considered to be one of the principal interfaces between the genome and our …
The dimensions, dynamics, and relevance of the mammalian noncoding transcriptome
The combination of pervasive transcription and prolific alternative splicing produces a
mammalian transcriptome of great breadth and diversity. The majority of transcribed …
mammalian transcriptome of great breadth and diversity. The majority of transcribed …
Heteromeric RNP assembly at LINEs controls lineage-specific RNA processing
J Attig, F Agostini, C Gooding, AM Chakrabarti, A Singh… - Cell, 2018 - cell.com
Long mammalian introns make it challenging for the RNA processing machinery to identify
exons accurately. We find that LINE-derived sequences (LINEs) contribute to this selection …
exons accurately. We find that LINE-derived sequences (LINEs) contribute to this selection …
[HTML][HTML] RNA-binding proteins: splicing factors and disease
AM Fredericks, KJ Cygan, BA Brown, WG Fairbrother - Biomolecules, 2015 - mdpi.com
Pre-mRNA splicing is mediated by interactions of the Core Spliceosome and an array of
accessory RNA binding proteins with cis-sequence elements. Splicing is a major regulatory …
accessory RNA binding proteins with cis-sequence elements. Splicing is a major regulatory …
[HTML][HTML] Exon-mediated activation of transcription starts
A Fiszbein, KS Krick, BE Begg, CB Burge - Cell, 2019 - cell.com
The processing of RNA transcripts from mammalian genes occurs in proximity to their
transcription. Here, we describe a phenomenon affecting thousands of genes that we call …
transcription. Here, we describe a phenomenon affecting thousands of genes that we call …
Widespread shortening of 3'untranslated regions and increased exon inclusion are evolutionarily conserved features of innate immune responses to infection
AA Pai, G Baharian, A Pagé Sabourin… - PLoS …, 2016 - journals.plos.org
The contribution of pre-mRNA processing mechanisms to the regulation of immune
responses remains poorly studied despite emerging examples of their role as regulators of …
responses remains poorly studied despite emerging examples of their role as regulators of …
A subset of replication-dependent histone mRNAs are expressed as polyadenylated RNAs in terminally differentiated tissues
Histone proteins are synthesized in large amounts during S-phase to package the newly
replicated DNA, and are among the most stable proteins in the cell. The replication …
replicated DNA, and are among the most stable proteins in the cell. The replication …