Promising nanomaterials in the fight against malaria
LN Borgheti-Cardoso, M San Anselmo… - Journal of Materials …, 2020 - pubs.rsc.org
For more than one hundred years, several treatments against malaria have been proposed
but they have systematically failed, mainly due to the occurrence of drug resistance in part …
but they have systematically failed, mainly due to the occurrence of drug resistance in part …
The evolutionary ecology of circadian rhythms in infection
Biological rhythms coordinate organisms' activities with daily rhythms in the environment.
For parasites, this includes rhythms in both the external abiotic environment and the within …
For parasites, this includes rhythms in both the external abiotic environment and the within …
Calcium signaling in a low calcium environment: how the intracellular malaria parasite solves the problem
Malaria parasites, Plasmodia, spend most of their asexual life cycle within red blood cells,
where they proliferate and mature. The erythrocyte cytoplasm has very low [Ca2+](< 100 …
where they proliferate and mature. The erythrocyte cytoplasm has very low [Ca2+](< 100 …
Plasmodium falciparum-Infected Erythrocytes Increase Intercellular Adhesion Molecule 1 Expression on Brain Endothelium through NF-κB
AK Tripathi, DJ Sullivan, MF Stins - Infection and immunity, 2006 - Am Soc Microbiol
Sequestration of Plasmodium falciparum-infected erythrocytes (Pf-IRBC) in postcapillary
brain endothelium is a hallmark of cerebral malaria (CM) pathogenesis. There is a …
brain endothelium is a hallmark of cerebral malaria (CM) pathogenesis. There is a …
Daily rhythms in mosquitoes and their consequences for malaria transmission
The 24-h day involves cycles in environmental factors that impact organismal fitness. This is
thought to select for organisms to regulate their temporal biology accordingly, through …
thought to select for organisms to regulate their temporal biology accordingly, through …
The life and times of parasites: rhythms in strategies for within-host survival and between-host transmission
Biological rhythms are thought to have evolved to enable organisms to organize their
activities according to the earth's predictable cycles, but quantifying the fitness advantages …
activities according to the earth's predictable cycles, but quantifying the fitness advantages …
Melatonin and IP3-induced Ca2+ release from intracellular stores in the malaria parasite Plasmodium falciparum within infected red blood cells
IP 3-dependent Ca 2+ signaling controls a myriad of cellular processes in higher eukaryotes
and similar signaling pathways are evolutionarily conserved in Plasmodium, the intracellular …
and similar signaling pathways are evolutionarily conserved in Plasmodium, the intracellular …
The Cinderella syndrome: why do malaria-infected cells burst at midnight?
An interesting quirk of many malaria infections is that all parasites within a host–millions of
them–progress through their cell cycle synchronously. This surprising coordination has long …
them–progress through their cell cycle synchronously. This surprising coordination has long …
Periodic parasites and daily host rhythms
Biological rhythms appear to be an elegant solution to the challenge of coordinating
activities with the consequences of the Earth's daily and seasonal rotation. The genes and …
activities with the consequences of the Earth's daily and seasonal rotation. The genes and …
Synthetic indole and melatonin derivatives exhibit antimalarial activity on the cell cycle of the human malaria parasite Plasmodium falciparum
DC Schuck, AK Jordão, M Nakabashi… - European Journal of …, 2014 - Elsevier
Discovering the mechanisms by which cell signaling controls the cell cycle of the human
malaria parasite Plasmodium falciparum is fundamental to designing more effective …
malaria parasite Plasmodium falciparum is fundamental to designing more effective …