Anabolic androgenic steroid (AAS) related deaths: autoptic, histopathological and toxicological findings

P Frati, F P. Busardo, L Cipolloni… - Current …, 2015 - benthamdirect.com
Anabolic androgenic steroids (AASs) represent a large group of synthetic derivatives of
testosterone, produced to maximize anabolic effects and minimize the androgenic ones …

Transient outward potassium current, 'Ito', phenotypes in the mammalian left ventricle: underlying molecular, cellular and biophysical mechanisms

SP Patel, DL Campbell - The Journal of physiology, 2005 - Wiley Online Library
At least two functionally distinct transient outward K+ current (Ito) phenotypes can exist
across the free wall of the left ventricle (LV). Based upon their voltage‐dependent kinetics of …

A mathematical model of action potential heterogeneity in adult rat left ventricular myocytes

SV Pandit, RB Clark, WR Giles, SS Demir - Biophysical journal, 2001 - cell.com
Mathematical models were developed to reconstruct the action potentials (AP) recorded in
epicardial and endocardial myocytes isolated from the adult rat left ventricle. The main goal …

Mechanisms of hypokalemia‐induced ventricular arrhythmogenicity

OE Osadchii - Fundamental & clinical pharmacology, 2010 - Wiley Online Library
Hypokalemia is a common biochemical finding in cardiac patients and may represent a side
effect of diuretic therapy or result from endogenous activation of renin–angiotensin system …

Comparison of contraction and calcium handling between right and left ventricular myocytes from adult mouse heart: a role for repolarization waveform

RP Kondo, DA Dederko, C Teutsch… - The Journal of …, 2006 - Wiley Online Library
In the mammalian heart, the right ventricle (RV) has a distinct structural and
electrophysiological profile compared to the left ventricle (LV). However, the possibility that …

[HTML][HTML] MiR-223-3p as a novel MicroRNA regulator of expression of voltage-gated K+ channel Kv4. 2 in acute myocardial infarction

X Liu, Y Zhang, W Du, H Liang, H He, L Zhang… - Cellular Physiology and …, 2016 - karger.com
Background/Aims: Acute myocardial infarction (AMI) is a devastating cardiovascular disease
with a high rate of morbidity and mortality, partly due to enhanced arrhythmogenicity …

Exploring functional differences between the right and left ventricles to better understand right ventricular dysfunction

J Bernal-Ramirez, MC Díaz-Vesga… - Oxidative Medicine …, 2021 - Wiley Online Library
The right and left ventricles have traditionally been studied as individual entities.
Furthermore, modifications found in diseased left ventricles are assumed to influence on …

Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents ITO and ISA

D Isbrandt, T Leicher, R Waldschütz, X Zhu… - Genomics, 2000 - Elsevier
The four known members of the KCND/Kv4 channel family encode voltage-gated potassium
channels. Recent studies provide evidence that members of the Kv4 channel family are …

Effects of diabetic cardiomyopathy on regional electrophysiologic characteristics of rat ventricle

O Casis, M Gallego, M Iriarte, JA Sanchez-Chapula - Diabetologia, 2000 - Springer
Aims/hypothesis. To identify the possible causes of the lengthening of the action potential
duration described in patients affected by diabetes mellitus.¶ Methods. We studied the …

Mechanisms underlying rate-dependent remodeling of transient outward potassium current in canine ventricular myocytes

L Xiao, P Coutu, LR Villeneuve, A Tadevosyan… - Circulation …, 2008 - Am Heart Assoc
Transient outward K+ current (I to) downregulation following sustained tachycardia in vivo is
usually attributed to tachycardiomyopathy. This study assessed potential direct rate …