Chronic inflammation underlies various debilitating disorders including autoimmune,
neurodegenerative, vascular and metabolic diseases as well as cancer, where aberrant …

Dendritic cells (DCs) mediate tolerance to food antigens, limit reactivity to the gut microbiota
and are required for optimal response to intestinal pathogens. Intestinal DCs are …

Mucosal healing plays a critical role in combatting the effects of inflammatory bowel disease,
fistulae and ulcers. While most treatments for such diseases focus on systemically delivered …

Commensal bacteria are believed to have important roles in human health. The
mechanisms by which they affect mammalian physiology remain poorly understood, but …

Abstract Prostaglandin E 2 (PGE 2) is a bioactive lipid that elicits a wide range of biological
effects associated with inflammation and cancer. PGE 2 exerts diverse effects on cell …

Little is known about the maintenance of intestinal stem cells (ISCs) and progenitors during
immune-mediated tissue damage or about the susceptibility of transplant recipients to tissue …

Recently, substantial advances in the understanding of the molecular pathogenesis of
inflammatory bowel disease (IBD) have been made owing to three related lines of …

Chronic viral infections often result in T cell exhaustion. To determine the molecular
signature of exhaustion, we compared the gene-expression profiles of dysfunctional …

Colorectal cancer (CRC) is a heterogeneous disease, including at least three major forms:
hereditary, sporadic and colitis-associated CRC. A large body of evidence indicates that …

Inflammation is a protective response to pathogens and injury. To be effective it needs to be
resolved by endogenous mechanisms in order to avoid prolonged and excessive …