[HTML][HTML] The mechanisms of pharmacokinetic food-drug interactions–A perspective from the UNGAP group
The simultaneous intake of food and drugs can have a strong impact on drug release,
absorption, distribution, metabolism and/or elimination and consequently, on the efficacy …
absorption, distribution, metabolism and/or elimination and consequently, on the efficacy …
The impact of food intake on the luminal environment and performance of oral drug products with a view to in vitro and in silico simulations: a PEARRL review
C Pentafragka, M Symillides… - Journal of Pharmacy …, 2019 - academic.oup.com
Objectives Using the type of meal and dosing conditions suggested by regulatory agencies
as a basis, this review has two specific objectives: first, to summarize our understanding on …
as a basis, this review has two specific objectives: first, to summarize our understanding on …
Selection of In Vivo Predictive Dissolution Media Using Drug Substance and Physiological Properties
DM Mudie, N Samiei, DJ Marshall, GE Amidon… - The AAPS journal, 2020 - Springer
The rate and extent of drug dissolution in the gastrointestinal (GI) tract are highly dependent
upon drug physicochemical properties and GI fluid properties. Biorelevant dissolution media …
upon drug physicochemical properties and GI fluid properties. Biorelevant dissolution media …
[HTML][HTML] A mechanistic physiologically-based biopharmaceutics modeling (PBBM) approach to assess the in vivo performance of an orally administered drug product …
M Bermejo, B Hens, J Dickens, D Mudie, P Paixão… - Pharmaceutics, 2020 - mdpi.com
The application of in silico modeling to predict the in vivo outcome of an oral drug product is
gaining a lot of interest. Fully relying on these models as a surrogate tool requires …
gaining a lot of interest. Fully relying on these models as a surrogate tool requires …
Simulated, biorelevant, clinically relevant or physiologically relevant dissolution media: The hidden role of bicarbonate buffer
In-vitro dissolution testing of pharmaceutical formulations has been used as a quality control
test for many years. At early drug product development, in vivo predictive dissolution testing …
test for many years. At early drug product development, in vivo predictive dissolution testing …
Hop Flower Supercritical Carbon Dioxide Extracts Coupled with Carriers with Solubilizing Properties—Antioxidant Activity and Neuroprotective Potential
A Stasiłowicz-Krzemień, J Cielecka-Piontek - Antioxidants, 2023 - mdpi.com
Lupuli flos shows many biological activities like antioxidant potential, extended by a targeted
effect on selected enzymes, the expression of which is characteristic for neurodegenerative …
effect on selected enzymes, the expression of which is characteristic for neurodegenerative …
Oral bioavailability of bioactive compounds; modulating factors, in vitro analysis methods, and enhancing strategies
Foods are complex biosystems made up of a wide variety of compounds. Some of them,
such as nutrients and bioactive compounds (bioactives), contribute to supporting body …
such as nutrients and bioactive compounds (bioactives), contribute to supporting body …
In Silico Modeling Approach for the Evaluation of Gastrointestinal Dissolution, Supersaturation, and Precipitation of Posaconazole
The aim of this study was to evaluate gastrointestinal (GI) dissolution, supersaturation, and
precipitation of posaconazole, formulated as an acidified (pH 1.6) and neutral (pH 7.1) …
precipitation of posaconazole, formulated as an acidified (pH 1.6) and neutral (pH 7.1) …
Co-dispersion delivery systems with solubilizing carriers improving the solubility and permeability of cannabinoids (cannabidiol, cannabidiolic acid, and …
A Stasiłowicz-Krzemień, P Szulc, J Cielecka-Piontek - Pharmaceutics, 2023 - mdpi.com
Cannabinoids: cannabidiol (CBD), cannabidiolic acid (CBDA), and cannabichromene (CBC)
are lipophilic compounds with limited water solubility, resulting in challenges related to their …
are lipophilic compounds with limited water solubility, resulting in challenges related to their …
In Vivo Dissolution and Systemic Absorption of Immediate Release Ibuprofen in Human Gastrointestinal Tract under Fed and Fasted Conditions
MJ Koenigsknecht, JR Baker, B Wen… - Molecular …, 2017 - ACS Publications
In vivo drug dissolution in the gastrointestinal (GI) tract is largely unmeasured. The purpose
of this clinical study was to evaluate the in vivo drug dissolution and systemic absorption of …
of this clinical study was to evaluate the in vivo drug dissolution and systemic absorption of …