Cutaneous melanoma (cM) is the deadliest of all primary skin cancers. Its prognosis is
strongly influenced by the stage at diagnosis, with early stages having a good prognosis and …

The lymphatic system is essential for transporting interstitial fluid, soluble antigen, and
immune cells from peripheral tissues to lymph nodes (LNs). Functional integrity of LNs is …

The aims of this study were to investigate the role of vascular invasion (blood and
lymphatic), vessel density and the presence of tumour-associated macrophages as …

The prognostic significance of the width of the ulceration in primary melanomas remains
unclear, and there is a relative paucity of data for lymphovascular invasion (LVI) …

Angiogenesis plays a crucial role in melanoma metastasis and progression. In recent years,
numerous studies have investigated the prognostic and clinical significance of this …

The dramatic recent advances in therapy of melanoma require a more personalized and
precise diagnostic approach to aid in clinical decisions. Tissue-based biomarkers in …

Earlier identification of aggressive melanoma remains a goal in the field of melanoma
research. With new targeted and immune therapies that have revolutionized the care of …

In malignant melanoma (MM) there is an urgent need to identify new markers with predictive
value superior to the traditional clinical and histological parameters. Angiogenesis and …

Immunohistochemistry (IHC) using endothelial markers may facilitate the detection of
lymphovascular invasion (LVI) in primary melanoma; however, the clinical implications of …

Purpose: Lymphatic invasion (LI) in primary cutaneous melanomas was recently found to be
common. In this study, we evaluated LI as an independent prognostic factor. Experimental …