Implications of the polymorphism of HLA-G on its function, regulation, evolution and disease association

EA Donadi, EC Castelli, A Arnaiz-Villena… - Cellular and molecular …, 2011 - Springer
The HLA-G gene displays several peculiarities that are distinct from those of classical HLA
class I genes. The unique structure of the HLA-G molecule permits a restricted peptide …

A comprehensive review of the genetics of juvenile idiopathic arthritis

S Prahalad, DN Glass - Pediatric Rheumatology, 2008 - Springer
Juvenile idiopathic arthritis (JIA) is the most common chronic arthropathy of childhood which
is believed to be influenced by both genetic and environmental factors. The progress in …

The genetic structure of 3′ untranslated region of the HLA-G gene: polymorphisms and haplotypes

EC Castelli, CT Mendes-Junior, NHS Deghaide… - Genes & …, 2010 - nature.com
The HLA-G gene is predominantly expressed at the maternal–fetal interface. It has been
associated with maternal–fetal tolerance and in the inhibition of cytotoxic T lymphocyte and …

Insights into HLA-G Genetics Provided by Worldwide Haplotype Diversity

EC Castelli, J Ramalho, IOP Porto, THA Lima… - Frontiers in …, 2014 - frontiersin.org
Human leukocyte antigen G (HLA-G) belongs to the family of non-classical HLA class I
genes, located within the major histocompatibility complex (MHC). HLA-G has been the …

The 14 bp deletion polymorphisms in HLA‐G gene play an important role in the expression of soluble HLA‐G in plasma

XY Chen, WH Yan, A Lin, HH Xu, JG Zhang… - Tissue …, 2008 - Wiley Online Library
Soluble human leukocyte antigen‐G (sHLA‐G) functions as a multiple immunoregulator. A
14 bp insertion (+ 14 bp)/deletion (− 14 bp) polymorphism in exon 8 of the HLA‐G gene has …

HLA-G molecules in autoimmune diseases and infections

R Rizzo, D Bortolotti, S Bolzani, E Fainardi - Frontiers in immunology, 2014 - frontiersin.org
Human leukocyte antigen (HLA)-G molecule, a non-classical HLA-Ib molecule, is less
polymorphic when compared to classical HLA class I molecules. Human leukocyte antigen …

Update on the epidemiology, risk factors and disease outcomes of Juvenile idiopathic arthritis

J Palman, S Shoop-Worrall, K Hyrich… - Best Practice & Research …, 2018 - Elsevier
Juvenile idiopathic arthritis (JIA) is the most common inflammatory joint condition of
childhood and represents seven JIA subtypes characterised by distinct clinical and …

Tolerance versus immune response—microRNAs as important elements in the regulation of the HLA-G gene expression

TD Veit, JAB Chies - Transplant immunology, 2009 - Elsevier
HLA-G is a class Ib HLA which has gained much attention due to its multiple functions on the
immune system. HLA-G exerts several immunomodulatory effects, being beneficially …

Human leukocyte antigen-G polymorphism in relation to expression, function, and disease

MH Larsen, TVF Hviid - Human immunology, 2009 - Elsevier
Human leukocyte antigen-G (HLA-G) is a nonclassical class Ib molecule belonging to the
major histocompatibility complex. HLA-G appears to play a role in the suppression of …

Genetic association between HLA-G 14-bp polymorphism and diseases: A systematic review and meta-analysis

BS de Almeida, YCN Muniz, AH Prompt, EC Castelli… - Human immunology, 2018 - Elsevier
Background HLA-G is an immune checkpoint molecule. Since a differential molecule
expression has been reported even for healthy individuals, many studies have focused on …