Noninvasive magnetic resonance imaging measures of glymphatic system activity

K Kamagata, Y Saito, C Andica… - Journal of Magnetic …, 2024 - Wiley Online Library
The comprehension of the glymphatic system, a postulated mechanism responsible for the
removal of interstitial solutes within the central nervous system (CNS), has witnessed …

[HTML][HTML] The glymphatic system in humans: investigations with magnetic resonance imaging

S Naganawa, T Taoka, R Ito… - Investigative …, 2024 - journals.lww.com
The concept of the glymphatic system was proposed more than a decade ago as a
mechanism for interstitial fluid flow and waste removal in the central nervous system. The …

Glymphatic system impairment in multiple sclerosis: relation with brain damage and disability

A Carotenuto, L Cacciaguerra, E Pagani, P Preziosa… - Brain, 2022 - academic.oup.com
Recent evidence has shown the existence of a CNS 'waste clearance'system, defined as the
glymphatic system. Glymphatic abnormalities have been described in several …

Magnetic resonance images implicate that glymphatic alterations mediate cognitive dysfunction in Alzheimer disease

JL Hsu, YC Wei, CH Toh, IT Hsiao, KJ Lin… - Annals of …, 2023 - Wiley Online Library
Objective The glymphatic system cleans amyloid and tau proteins from the brain in animal
studies of Alzheimer disease (AD). However, there is no direct evidence showing this in …

Altered brain glymphatic flow at diffusion-tensor MRI in rapid eye movement sleep behavior disorder

YJ Bae, JM Kim, BS Choi, N Ryoo, YS Song, Y Nam… - Radiology, 2023 - pubs.rsna.org
Background Brain glymphatic dysfunction may contribute to the development of α-
synucleinopathies. Yet, noninvasive imaging and quantification remain lacking. Purpose To …

[HTML][HTML] Diffusion tensor imaging along the perivascular space index in different stages of Parkinson's disease

X Ma, S Li, C Li, R Wang, M Chen, H Chen… - Frontiers in Aging …, 2021 - frontiersin.org
Background: The aim of this study was to evaluate the glymphatic system activity in patients
with Parkinson's disease (PD) using the diffusion tensor image analysis along the …

Glymphatic system dysfunction in obstructive sleep apnea evidenced by DTI-ALPS

HJ Lee, DA Lee, KJ Shin, KM Park - Sleep Medicine, 2022 - Elsevier
Objectives This study aimed to evaluate the glymphatic system function in patients with
obstructive sleep apnea (OSA) compared to healthy controls using diffusion tensor imaging …

Impaired glymphatic system as evidenced by low diffusivity along perivascular spaces is associated with cerebral small vessel disease: a population-based study

Y Tian, X Cai, Y Zhou, A Jin, S Wang, Y Yang… - Stroke and Vascular …, 2023 - svn.bmj.com
Objective This study aims to investigate the associations of glymphatic system with the
presence, severity and neuroimaging phenotypes of cerebral small vessel disease (CSVD) …

[HTML][HTML] Glymphatic dysfunction in patients with ischemic stroke

CH Toh, TY Siow - Frontiers in aging neuroscience, 2021 - frontiersin.org
Objectives: Rodent experiments have provided some insight into the changes of glymphatic
function in ischemic stroke. The diffusion tensor image analysis along the perivascular …

[HTML][HTML] Neuroimaging findings related to glymphatic system alterations in older adults with metabolic syndrome

C Andica, K Kamagata, K Takabayashi, J Kikuta… - Neurobiology of …, 2023 - Elsevier
Objective The glymphatic system is a glial-based perivascular network that promotes brain
metabolic waste clearance. Reduced glymphatic flow has been observed in rat models of …