Cellulosic polymers for enhancing drug bioavailability in ocular drug delivery systems

B Gupta, V Mishra, S Gharat, M Momin, A Omri - Pharmaceuticals, 2021 - mdpi.com
One of the major impediments to drug development is low aqueous solubility and thus poor
bioavailability, which leads to insufficient clinical utility. Around 70–80% of drugs in the …

CRISPR-based genome editing as a new therapeutic tool in retinal diseases

SA Rasoulinejad, F Maroufi - Molecular Biotechnology, 2021 - Springer
Retinal diseases are the primary reasons for severe visual defects and irreversible
blindness. Retinal diseases are also inherited and acquired. Both of them are caused by …

Inducible caspase 9-mediated suicide gene therapy using AAV6 vectors in a murine model of breast cancer

S Pathak, V Singh, N Kumar… - … Therapy Methods & …, 2023 - cell.com
Breast carcinoma has one of the highest incidence rates (11.7%), with significant clinical
heterogeneity. Although conventional chemotherapy and surgical resection are the current …

Advances in designing Adeno-associated viral vectors for development of anti-HBV gene therapeutics

N Mnyandu, SW Limani, P Arbuthnot, MB Maepa - Virology Journal, 2021 - Springer
Despite the five decades having passed since discovery of the hepatitis B virus (HBV),
together with development of an effective anti-HBV vaccine, infection with the virus remains …

CRISPR technology: Progress and application in retinal medicine

OA Sibeudu, ON Okonkwo - Nigerian Journal of Vitreoretinal …, 2022 - journals.lww.com
CRISPR is the most popular gene-editing technique. It represents an acronym for “clustered
regularly interspaced short palindromic repeats.” In this era of retinal medicine, the frontier of …

[PDF][PDF] Advances in designing Adeno-associated viral vectors for development of anti-HBV gene

N Mnyandu, SW Limani, P Arbuthnot, MB Maepa - 2021 - virologyj.biomedcentral.com
Despite the five decades having passed since discovery of the hepatitis B virus (HBV),
together with development of an effective anti-HBV vaccine, infection with the virus remains …