Cancer elimination in humans can be achieved with immunotherapy that relies on T
lymphocyte-mediated recognition of tumor antigens. Several types of these antigens have …

Long intergenic non-coding RNA (lincRNA) genes have diverse features that distinguish
them from mRNA-encoding genes and exercise functions such as remodelling chromatin …

In castration-resistant prostate cancer (CRPC), the loss of androgen receptor (AR)
dependence leads to clinically aggressive tumors with few therapeutic options. We used …

Transformers-based models, such as BERT, have been one of the most successful deep
learning models for NLP. Unfortunately, one of their core limitations is the quadratic …

The mechanistic understanding of nascent RNAs in transcriptional control remains limited.
Here, by a high sensitivity method methylation-inscribed nascent transcripts sequencing …

Tumor-specific antigens (TSAs) represent ideal targets for cancer immunotherapy, but few
have been identified thus far. We therefore developed a proteogenomic approach to enable …

Cell type-and differentiation-specific gene expression is precisely controlled by genomic non-
coding regulatory elements (NCREs), which include promoters, enhancers, silencers and …

Non-coding RNAs represent a significant proportion of the human genome. After having
been considered as 'junk'for a long time, non-coding RNAs are now well established as …

Tumour formation involves random mutagenic events and positive evolutionary selection
acting on a subset of such events, referred to as driver mutations. A decade of careful …

Long noncoding RNAs (lncRNAs), which are encoded by a vast less explored region of the
human genome, may hold missing drivers of cancer and have gained attention recently as a …