The function of the immune system declines during aging, compromising its response
against pathogens, a phenomenon termed as “immunosenescence.” Alterations of the …

The role of the autoimmune regulator (Aire) in central immune tolerance and thymic self-
representation was first described more than 20 years ago, but fascinating new insights into …

Hepatitis B virus (HBV)-specific CD8+ T cells play a dominant role during acute-resolving
HBV infection but are functionally impaired during chronic HBV infection in humans. These …

T cells develop from circulating precursor cells, which enter the thymus and migrate through
specialized subcompartments that support their maturation and selection. In humans, this …

Thymus is necessary for lifelong immunological tolerance and immunity. It displays a
distinctive epithelial complexity and undergoes age-dependent atrophy. Nonetheless, it also …

Central tolerance of thymocytes to self-antigen depends on the medullary thymic epithelial
cell (mTEC) transcription factor autoimmune regulator (Aire), which drives tissue-restricted …

The thymus medulla is a key site for immunoregulation and tolerance, and its functional
specialisation is achieved through the complexity of medullary thymic epithelial cells …

While γδ T cells are present virtually in all vertebrates, there is a remarkable lack of
conservation of the TRG and TRD loci underlying the generation of the γδ T cell receptor …

A paradigm for biology is emerging in which cells can be genetically programmed to write
their histories into their own genomes. These records can subsequently be read, and the …

Distinct pathways and molecules may support embryonic versus postnatal thymic epithelial
cell (TEC) development and maintenance. Here, we identify a mechanism by which TEC …