The effective and safe treatment of pain is an unmet health-care need. Current medications
used for pain management are often only partially effective, carry dose-limiting adverse …

Introduction: Chronic pain is a massive clinical problem. We discuss the potential of subtype
selective sodium channel blockers that may provide analgesia with limited side effects …

Voltage-gated sodium (NaV) channels are a family of transmembrane ion channel proteins.
They function by forming a gated, water-filled pore to help establish and control cell …

Neuropathic pain arises from injury to the nervous system. Conditions associated with
neuropathic pain are diverse, and lesions and/or pathological changes in the central …

Voltage-gated sodium channel blockers are one of the vital targets for the management of
several central nervous system diseases, including epilepsy, chronic pain, psychiatric …

Disorders of the somatosensory system such as neuropathic pain are common in people
with chronic neurologic and musculoskeletal diseases, yet these conditions remain an …

Voltage-gated sodium ion channel subtype 1.7 (NaV1. 7) is a high interest target for the
discovery of non-opioid analgesics. Compelling evidence from human genetic data …

Highlights•The structures and functions of VGSCs are briefly outlined.•The major binding
sites and isoform-selective modulators of VGSCs are summarized.•The studies on the …

Tropomyosin receptor kinases (TrkA, TrkB, TrkC) are activated by hormones of the
neurotrophin family: nerve growth factor (NGF), brain derived neurotrophic factor (BDNF) …

Pitt-Hopkins syndrome (PTHS) is a rare autism spectrum-like disorder characterized by
intellectual disability, developmental delays, and breathing problems involving episodes of …