Epigenetics, fragmentomics, and topology of cell-free DNA in liquid biopsies
BACKGROUND Liquid biopsies that are based on analysis of cell-free DNA from plasma
offer diagnostic information that is otherwise accessible conventionally through invasive …
offer diagnostic information that is otherwise accessible conventionally through invasive …
Extrachromosomal DNA amplifications in cancer
E Yi, R Chamorro González, AG Henssen… - Nature Reviews …, 2022 - nature.com
Extrachromosomal DNA (ecDNA) amplification is an important driver alteration in cancer. It
has been observed in most cancer types and is associated with worse patient outcome. The …
has been observed in most cancer types and is associated with worse patient outcome. The …
eccDNAs are apoptotic products with high innate immunostimulatory activity
Extrachromosomal circular DNA elements (eccDNAs) have been described in the literature
for several decades, and are known for their broad existence across different species …
for several decades, and are known for their broad existence across different species …
Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers
Extrachromosomal DNA (ecDNA) amplification promotes intratumoral genetic heterogeneity
and accelerated tumor evolution,–; however, its frequency and clinical impact are unclear …
and accelerated tumor evolution,–; however, its frequency and clinical impact are unclear …
Circular ecDNA promotes accessible chromatin and high oncogene expression
Oncogenes are commonly amplified on particles of extrachromosomal DNA (ecDNA) in
cancer,, but our understanding of the structure of ecDNA and its effect on gene regulation is …
cancer,, but our understanding of the structure of ecDNA and its effect on gene regulation is …
Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma
Extrachromosomal circularization of DNA is an important genomic feature in cancer.
However, the structure, composition and genome-wide frequency of extrachromosomal …
However, the structure, composition and genome-wide frequency of extrachromosomal …
[HTML][HTML] Extrachromosomal circular DNA in cancer: history, current knowledge, and methods
Extrachromosomal circular DNA (eccDNA) is a closed-circle, nuclear, nonplasmid DNA
molecule found in all tested eukaryotes. eccDNA plays important roles in cancer …
molecule found in all tested eukaryotes. eccDNA plays important roles in cancer …
Extrachromosomal oncogene amplification in tumour pathogenesis and evolution
Recent reports have demonstrated that oncogene amplification on extrachromosomal DNA
(ecDNA) is a frequent event in cancer, providing new momentum to explore a phenomenon …
(ecDNA) is a frequent event in cancer, providing new momentum to explore a phenomenon …
Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells
R Chamorro González, T Conrad, MC Stöber, R Xu… - Nature Genetics, 2023 - nature.com
Extrachromosomal DNAs (ecDNAs) are common in cancer, but many questions about their
origin, structural dynamics and impact on intratumor heterogeneity are still unresolved. Here …
origin, structural dynamics and impact on intratumor heterogeneity are still unresolved. Here …
Extrachromosomal circular DNA and structural variants highlight genome instability in Arabidopsis epigenetic mutants
Abundant extrachromosomal circular DNA (eccDNA) is associated with transposable
element (TE) activity. However, how the eccDNA compartment is controlled by epigenetic …
element (TE) activity. However, how the eccDNA compartment is controlled by epigenetic …