Exercise blood pressure and heart rate responses to graded exercise testing in intermediate versus morning chronotypes with obesity

MME Remchak, JK Dosik, G Pappas… - American Journal …, 2023 - journals.physiology.org
Exaggerated exercise blood pressure (BP) is linked to cardiovascular disease (CVD).
Although evening chronotypes have greater CVD risk than morning (Morn) types, it is …

Insulin sensitivity and metabolic flexibility parallel plasma TCA levels in early chronotype with metabolic syndrome

MME Remchak, EM Heiston… - The Journal of …, 2022 - academic.oup.com
Context People characterized as late chronotype have elevated type 2 diabetes and
cardiovascular disease risk compared to early chronotype. It is unclear how chronotype is …

Tracking Biomarker Responses to Exercise in Hypertension

E Trillaud, P Klemmer, SK Malin… - Current Hypertension …, 2023 - Springer
Abstract Purpose of Review Strong evidence is evolving that physical exercise prevents
hypertension and reduces blood pressure in patients with pre-and manifest HTN. Yet …

Extracellular Vesicles in Metabolic and Vascular Insulin Resistance

SK Malin, U Erdbrügger - Journal of Vascular Research, 2024 - karger.com
Background: Insulin resistance is a major etiological factor in obesity, type 2 diabetes, and
cardiovascular disease (CVD). Endothelial dysfunction may precede impairments in …

Insulin infusion decreases medium-sized extracellular vesicles in adults with metabolic syndrome

EM Heiston, A Ballantyne, NR Stewart… - American Journal …, 2022 - journals.physiology.org
Elevated extracellular vesicles (EVs) are associated with glucose dysmetabolism. However,
the effects of insulin on EVs and subsequent relationships with insulin sensitivity, substrate …

Aortic waveform responses to insulin in late versus early chronotype with metabolic syndrome

MME Remchak, EM Heiston, A Ballantyne… - Physiological …, 2022 - Wiley Online Library
Late chronotype (LC) correlates with reduced metabolic insulin sensitivity and
cardiovascular disease. It is unclear if insulin action on aortic waveforms and inflammation is …

Acute exercise decreases insulin‐stimulated extracellular vesicles in conjunction with augmentation index in adults with obesity

EM Heiston, A Ballantyne, S La Salvia… - The Journal of …, 2023 - Wiley Online Library
Extracellular vesicles (EVs) are often elevated in obesity and may modulate disease risk.
Although acute exercise reduces fasting EVs in adults with obesity, no data exist on insulin …

Intermediate versus morning chronotype has lower vascular insulin sensitivity in adults with obesity

SK Malin, MME Remchak, EM Heiston… - Diabetes, Obesity …, 2024 - Wiley Online Library
Aim Chronotype reflects a circadian rhythmicity that regulates endothelial function. While the
morning chronotype (MORN) usually has low cardiovascular disease risk, no study has …

Extracellular vesicles and insulin‐mediated vascular function in metabolic syndrome

TJ Ragland, EM Heiston, A Ballantyne… - Physiological …, 2023 - Wiley Online Library
Abstract Metabolic Syndrome (MetS) raises cardiovascular disease risk. Extracellular
vesicles (EVs) have emerged as important mediators of insulin sensitivity, although few …

Impact of Insulin-Induced Relative Hypoglycemia on Vascular Insulin Sensitivity and Central Hemodynamics in Prediabetes

DJ Battillo, MME Remchak, AM Shah… - The Journal of Clinical …, 2024 - academic.oup.com
Context Relative hypoglycemia (RH) is linked to sympathetic responses that can alter
vascular function in individuals with type 2 diabetes. However, less is known about the role …