Endogenous bioactive lipids are part of a complex network that modulates a plethora of
cellular and molecular processes involved in health and disease, of which inflammation …

The Hippo pathway is a potent regulator of cellular proliferation, differentiation, and tissue
homeostasis. Here we review the regulatory mechanisms of the Hippo pathway and discuss …

Objective Iron deficiency is a common complication in patients with IBD and oral iron therapy
is suggested to exacerbate IBD symptoms. We performed an open-labelled clinical trial to …

Gastrointestinal motility disorders involve alterations to the structure and/or function of the
enteric nervous system (ENS) but the causal mechanisms remain unresolved in most cases …

Growing evidence indicates the vital role of lipid metabolites in innate immunity. The lipid
lysophosphatidic acid (LPA) concentrations are enhanced in patients upon HCV or SARS …

Gintonin, newly extracted from ginseng, is a glycoprotein that acts as an exogenous
lysophosphatidic acid (LPA) receptor ligand. This study aimed to demonstrate the in vivo …

Improving the long-term prognosis of ulcerative colitis (UC) requires sustained deep
mucosal colonic healing with histologic remission, making the study of colonic tissue …

We now have an increased understanding of the genetics, cell biology, and physiology of
electrolyte transport processes in the mammalian intestine, due to the availability of …

Peritoneal dissemination and malignant ascites in pancreatic ductal adenocarcinoma
(PDAC) patients represent a major clinical issue. Lysophosphatidic acid (LPA) is a lipid …

The tight junction (TJ) and barrier function of colonic epithelium is highly sensitive to ionizing
radiation. We evaluated the effect of lysophosphatidic acid (LPA) and its analog …