Decision making is one of the most complex skills required of an oncologist and is affected
by a broad range of parameters. For example, the wide variety of treatment options, with …

Simple Summary Medulloblastoma is the most common pediatric brain tumor, comprising
one-third of all pediatric brain tumors, and originating in the posterior fossa of the brain. The …

This study is the first proof of concept that the FLASH effect can be triggered by X-rays. Our
results show that a 10 Gy whole-brain irradiation delivered at ultra-high dose-rate with …

Major advances in high precision treatment delivery and imaging have greatly improved the
tolerance of radiotherapy (RT); however, the selective sparing of normal tissue and the …

Background Standard-of-care therapies for treating pediatric medulloblastoma have long-
term side effects, even in children who are cured. One emerging modality of cancer therapy …

Medulloblastoma is a malignant tumor of the cerebellum and the most frequent malignant
brain tumor in children. The standard of care consists of maximal resection surgery, followed …

Medulloblastoma (MB) is a malignant pediatric brain tumor arising in the cerebellum.
Although abnormal GABAergic receptor activation has been described in MB, studies have …

Brain tumors are the leading cause of cancer-related death in children, and
medulloblastoma (MB) is the most common malignant pediatric brain tumor. Advances in …

Medulloblastoma is the most frequent malignant childhood brain tumor with a high morbidity.
Identification of new therapeutic targets would be instrumental in improving patient …

Medulloblastoma (MB) is a high-grade pediatric brain malignancy that originates from
neuronal precursors located in the posterior cranial fossa. In this study, we evaluated the …