IL-17, a potent proinflammatory cytokine, has been shown to intimately contribute to the
formation, growth, and metastasis of a wide range of malignancies. Recent studies implicate …

Evidence has increasingly shown that the lungs are a major site of immune regulation. A
robust and highly regulated immune response in the lung protects the host from pathogen …

Staphylococcus aureus is the most common cause of skin and soft tissue infections, and
rapidly emerging antibiotic-resistant strains are creating a serious public health concern. If …

Whooping cough caused by Bordetella pertussis is a re-emerging infectious disease despite
the introduction of safer acellular pertussis vaccines (Pa). One explanation for this is that Pa …

We sought to define protective mechanisms of immunity to Staphylococcus aureus and
Candida albicans bloodstream infections in mice immunized with the recombinant N …

Th17 immunity in the gastrointestinal tract is regulated by the intestinal microbiota
composition, particularly the presence of segmented filamentous bacteria (sfb), but the role …

5 Magro C, Mulvey JJ, Berlin D et al. Complement associated microvascular injury and
thrombosis in the pathogenesis of severe COVID-19 infection: a report of five cases. Transl …

Abstract Cytokines IL-17 and IL-22 play pivotal roles in host defense against microbes and
in the development of chronic inflammatory diseases. These cytokines are produced by cells …

Respiratory infections and diseases are among the leading causes of death worldwide, and
effective treatments probably require manipulating the inflammatory response to pathogenic …

Abstract Interleukin 17 (IL-17) is a central cytokine implicated in inflammation and
antimicrobial defense. After infection, both innate and adaptive IL-17 responses have been …