STAT3 and STAT5 proteins are oncogenic downstream mediators of the JAK–STAT
pathway. Deregulated STAT3 and STAT5 signaling promotes cancer cell proliferation and …

The activity of the glucocorticoid receptor (GR), a nuclear receptor transcription factor
belonging to subclass 3C of the steroid/thyroid hormone receptor superfamily, is typically …

Through a comprehensive review and in silico analysis of reported data on STAT‐linked
diseases, we analysed the communication pathways and interactome of the seven STATs in …

Glucocorticoids (GCs) are broadly prescribed for numerous pathological conditions because
of their anti-inflammatory, antiallergic and immunosuppressive effects, among other actions …

Signal transducers and activators of transcription 5 (STAT5a and STAT5b) are highly
homologous proteins that are encoded by 2 separate genes and are activated by Janus …

Steroid resistance poses a major challenge for the management of autoimmune
neuroinflammation. T helper 17 (TH17) cells are widely implicated in the pathology of steroid …

Transcription factors from the family of Signal Transducers and Activators of Transcription
(STAT) are activated by numerous cytokines. Two members of this family, STAT5A and …

This paper reviews work on progesterone and the progesterone receptor (PR) in the mouse
mammary gland that has been used extensively as an experimental model. Studies have led …

Glucocorticoids (GCs) regulate cell fate by altering gene expression via the glucocorticoid
receptor (GR). Ligand-bound GR can activate the transcription of genes carrying the specific …

Glucocorticoid hormones (GCs)—acting through hippocampal mineralocorticoid receptors
(MRs) and glucocorticoid receptors (GRs)—are critical to physiological regulation and …